Antibacterial Effect and Postoperative Pain After Triton Irrigation Protocol in Necrotic Mandibular Molar

NCT07435883 · tracked via the Priya Life Science Egypt tracker

Sponsor

sara hosny mostafa

Phase

Not applicable

Started

2026-03

Last updated

2026-02-27

Condition(s) studied

Pulp Necrosis

Investigational drug(s) / intervention(s)

triton irrigation protocolconventional irrigation group

triton irrigation protocol: Root canal irrigation performed using Triton solution according to a standardized endodontic irrigation protocol during root canal treatment.

conventional irrigation group: Participants receive conventional root canal irrigation using standard irrigation solutions during chemo-mechanical preparation according to the routine clinical protocol.

Study summary

This randomized clinical study evaluates the antibacterial effectiveness and postoperative pain following root canal irrigation using the Triton irrigation protocol in necrotic mandibular molars. Thirty-six patients requiring root canal treatment will be included. The study aims to compare bacterial reduction and postoperative pain outcomes after treatment. Results may help improve irrigation protocols and patient comfort during endodontic therapy.

Eligibility

Sex

ALL

Min age

18 Years

Max age

45 Years

Healthy volunteers

Inclusion Criteria: * Patients aged 18-45 years with no sex predilection * Medically free Patients with no systemic conditions that can affect post operative pain response. * Patients should not be taking any pain medications 24 hours before intervention * Positive patients' acceptance for participating in the study * Patient able to sign informed consent * Permanent mandibular molars diagnosis with pulpal necrosis with asymptomatic apical periodontitis. * Mandibular molars without any anatomical variations or severe curvatures with mesial roots configuration weine class 3 and a distal root with 2 distal canals Exclusion Criteria: * Medically compromised patients * Patients who have received antibiotic therapy within the last 2 weeks. * Pregnant or lactating women. * Patients with known allergy to any of the irrigants used. * Patients with swelling or acute peri-apical abscess or fistulous tract. * Teeth that have: * Wide or open apex . * Vital pulp tissue .

Primary outcome measure(s)

antibacterial effect — immediately after irrigation procedures
Reduction in bacterial count will be evaluated by microbiological sampling before and after irrigation.

Trial sites (1)

Facility	City	Region	Status
Faculty of Oral and Dental Medicine , Future University in Egypt	Cairo	New Cairo

Other trials for the same condition

Evaluation of Post-operative Pain and Bacterial Load Reduction After Application of Three Intra-canal Medications (Cocoa Husk Versus Calcium Hydroxide With and Without Cocoa) in Necrotic Mandibular First Molar. Active, not recruiting

Efficiency of Asiaticoside as Intracanal Medication in Revascularization Process Recruiting

Conventional and Nano-Metronidazole Irrigation With/Without Activation in Necrotic Teeth With Apical Periodontitis Recruiting

Moringa Oleifera vs Sodium Hypochlorite for Root Canal Irrigation in Nonvital Primary Molars Starting soon

Regenerative Root Canal Treatment of Immature Teeth Using Omega-3 Fatty Acids Active, not recruiting

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07435883 on ClinicalTrials.gov ↗ ← All trials in Egypt