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Clinical Trials in Egypt / NCT07790796
Active, not recruiting Not applicable

Evaluation of Post-operative Pain and Bacterial Load Reduction After Application of Three Intra-canal Medications (Cocoa Husk Versus Calcium Hydroxide With and Without Cocoa) in Necrotic Mandibular First Molar.

NCT07790796 · tracked via the Priya Life Science Egypt tracker
Sponsor
Future University in Egypt
Phase
Not applicable
Started
2026-01-06
Last updated
2026-08-27

Condition(s) studied

Pulp NecrosisPostoperative Pain

Investigational drug(s) / intervention(s)

Root canal treatment with intracanal medication by calcium hydroxide for one week.Root canal treatment with intracanal medication by cocoa husk for one weekRoot canal treatment with intracanal medication by calcium hydroxide with cocoa husk for one week.

Root canal treatment with intracanal medication by calcium hydroxide for one week.: Following cleaning and shaping of the root canal, calcium hydroxide paste will be used as an intracanal medicament for one week to reduce bacterial load before the final root canal

Root canal treatment with intracanal medication by cocoa husk for one week: Root canal treatment with intracanal medication by cocoa husk for one week

Root canal treatment with intracanal medication by calcium hydroxide with cocoa husk for one week.: Following cleaning and shaping, no intracanal medicament will be used. The root canal will be obturated according to the study protocol.

Study summary

The study will aim to evaluate the postoperative pain and bacterial load after application of two intracanal medications in mandibular first molar teeth with necrotic pulp.

Methods (Participants, Interventions, and Outcomes)

Study Setting:

This randomized clinical trial will include 36 patients, equally allocated into three groups (12 patients each). Participants will be recruited from the Outpatient Clinic of the Endodontic Department, Faculty of Oral and Dental Medicine, Future University in Egypt. All treatments will be performed by a postgraduate master's degree candidate using a Ritter dental unit (Germany) and Sirona digital intraoral radiography (Nanopix, size 2).

Eligibility Criteria:

Eligible participants will be 18-40 years old with necrotic pulp and symptomatic apical periodontitis in restorable mandibular first molars (Type III mesial and distal canals) and willing to participate. Exclusion criteria include pregnancy, systemic diseases, recent use of analgesics or antibiotics, bruxism or clenching, severe traumatic malocclusion, and teeth with periapical radiolucency, root resorption, pulp stones/calcifications, or previous endodontic treatment.

Eligibility

Sex
ALL
Min age
18 Years
Max age
40 Years
Healthy volunteers
Accepted
Inclusion Criteria:1. Patients with an age range between 18 to 40. 2. Patients with necrotic pulp. 3. Restorable teeth. 4. Positive patient acceptance for participating in the study. 5. Type III distal and mesial canal of the first mandibular molar. 6. Patients have necrotic pulp with symptomatic apical periodontitis in mandibular first molars. \- Exclusion Criteria:1. Pregnant females 2. Medically compromised patients. 3. Patients having analgesics before the treatment 4. If antibiotics have been administered during the past two weeks pre-operatively. 5\. Patients having bruxism or clenching 6. Patients have severe malocclusion associated with traumatic occlusion. 7. Teeth that have: a. Peri-apical radiolucency b. Root resorption. c. Pulp stones or calcifications. d. Previous endodontic treatment \-

Primary outcome measure(s)

Trial sites (1)

FacilityCityRegionStatus
Future University Cairo Egypt

More Future University in Egypt trials in Egypt

The Impact of Using Different Final Irrigation Modes on Postoperative Pain Following Root Canal Treatment of Non-vital Mandibular First Molar With Periapical Lesion. Active, not recruiting
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Evaluation of Postoperative Pain and Bacterial Load After Hyalone or Calcium Hydroxide Medication in Mandibular First Molars Active, not recruiting
Maxillary Positioning in Orthognathic Surgery Enrolling by invitation
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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07790796 on ClinicalTrials.gov ↗ ← All trials in Egypt