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Clinical Trials in Egypt / NCT07623629
Active, not recruiting Not applicable

The Impact of Using Different Final Irrigation Modes on Postoperative Pain Following Root Canal Treatment of Non-vital Mandibular First Molar With Periapical Lesion.

NCT07623629 · tracked via the Priya Life Science Egypt tracker
Phase
Not applicable
Started
2026-01-03
Last updated
2026-06-03

Condition(s) studied

Necrotic Pulp With Symptomatic Apical Periodontitis

Investigational drug(s) / intervention(s)

root canal treatment

root canal treatment: single visit root canal treatment with final irrigation protocol according to arm

Study summary

The goal of this clinical trial is to learn which rinsing of root canals method works best to lower pain after a root canal in adults. The study focuses on participants aged 20 to 40 with an infection in a lower back tooth (mandibular first molar) and a small area of bone loss at the root tip.

The main questions it aims to answer are:

Does the type of tool used to rinse the tooth root canal change how much pain a participant feels after treatment?

Does the cleaning method lower the number of painkillers a participant needs to take?

Researchers will compare four different rinsing tools-ranging from a standard needle to advanced vacuum and vibration devices-to see if using suction and sound waves can lower pain levels.

Participants will:

Receive a complete root canal treatment in a single visit

Be randomly assigned to one of four cleaning groups (standard rinse, vibration, vacuum, or a combination of both)

Rate their pain on a scale of 0 to 10 at five specific times: before the visit, and at 6, 12, 24, and 48 hours after treatment

Record how many painkiller tablets (Ibuprofen) they take during the two days following the procedure

Eligibility

Sex
ALL
Min age
20 Years
Max age
40 Years
Healthy volunteers
Accepted
Inclusion Criteria: * Lower first molar Classification of root canal configuration according to weine classification: - * Distal root: any type of root canal configuration given that the portal of exit is through only one apical foramen * Mesial root: any type of root canal configuration given that the portal of exit is through only one apical foramen(18). * Patient with mild pre-operative pain with pain score from 0-3 * Medically free patients with no systemic disease: (American Society of Anesthesiologists / (ASA Class I or II). * The age range is between 20 to 40 years. * Patients have restorable lower permanent molars that were diagnosed with symptomatic apical periodontitis with small to moderate periapical lesion. * Positive patient's acceptance for participating in the study. * Patients able to sign informed consent. Exclusion Criteria: * Patients with systemic conditions that may affect pain perception (e.g., fibromyalgia, chronic pain disorders) * Patients currently taking or taken analgesics or anti-inflammatory medications before the trial in the last 12 hours. * Pregnant or lactating females. * Psychologically disturbed patients. * Patients with a history of allergy to any medication used in the study are excluded. Teeth that have: * Periodontally affected with grade 2 or 3 mobility. * Not restorable teeth. * Abnormal anatomy and calcified canals. * Previous root canal treatment. * Any patient that matched the inclusion criteria, however had an unintentional errors during procedure, eg: over-instrumentation/over-obturation.

Primary outcome measure(s)

Trial sites (1)

FacilityCityRegionStatus
Future University in Egypt Cairo New Cairo

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Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07623629 on ClinicalTrials.gov ↗ ← All trials in Egypt