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Clinical Trials in China / NCT05968313
Recruiting Observational

Altered Neural Pain Empathic Reactivity in NSSI Adolescents

NCT05968313 · tracked via the Priya Life Science China tracker
Sponsor
University of Electronic Science and Technology of China
Phase
Observational
Started
2023-12-06
Last updated
2024-04-11

Condition(s) studied

Nonsuicidal Self InjuryPain Empathy

Study summary

Nonsuicidal self-injury (NSSI) is defined as direct, deliberate bodily harm without suicidal intention. In recent years, growing evidence suggests that NSSI has become a worldwide public health issue. People with NSSI behaviors, especially adolescents, commonly exhibit emotion-related and interpersonal problems. Pain empathy represents an essential basal domain of socio-emotional processing and refers to the ability to empathize, connect and share with others' pain. However, altered empathic processing has not been systematically examined in adolescents with NSSI. To this end, the current functional magnetic resonance imaging (fMRI) study will recruit one group of NSSI adolescents (n=40) and one healthy control (HC) group (n=40), to compare their neural activity regarding pain empathy processing, which is measured by blood oxygenation level-dependent (BOLD) fMRI. The investigators included conditions of physical pain empathy (stimuli depicting noxious stimulation to the limbs) and affective pain empathy (stimuli depicting faces expressing pain) as well as corresponding control stimuli. The investigators hypothesize that compared to HC, NSSI adolescents show increased empathic reactivity to physical pain stimuli in salience and arousal related brain regions but decreased empathic reactivity to affective pain empathic stimuli.

Eligibility

Sex
ALL
Min age
15 Years
Max age
18 Years
Healthy volunteers
Accepted
Inclusion Criteria: * 15-18 years * right-handed * normal or corrected normal visual acuity * meet the proposed DSM-5 frequency criteria (e.g., ≥5 days of NSSI behaviors in the past year) Exclusion Criteria: * diagnosis of borderline personality disorder, major depressive disorder, other * psychiatric disorders, etc. * high suicidal risk * recent use of medications that can affect neural activity * have received or are receiving Dialectical Behavior Therapy (DBT) other treatment for emotional problems within the past 6 months * have a contraindication to MRI scanning (e.g., metal implants, claustrophobia or other conditions that make them inappropriate for MRI scanning)

Primary outcome measure(s)

  • Neural activity as indexed by BOLD fMRI — About 8 minutes
    Brain activity will be monitored by task-based fMRI. The paradigm will present affective and physical pain empathy pictures and matched control stimuli. Alterations in the patients will be determined by comparing neural activity to the experimental conditions between the experimental groups (NSSI vs. HC) using ANOVA models.

Trial sites (1)

FacilityCityRegionStatus
Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China Chengdu Sichuan Recruiting

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Other trials for the same condition

Emotion Regulation Dysfunctions in NSSI Adolescents in Naturalistic Contexts Recruiting
Social Feedback and Dysfunctional Risk Taking in NSSI Adolescents Recruiting
Impact of Emotional Reactivity on Dysfunctional Decision-Making in NSSI Adolescents Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05968313 on ClinicalTrials.gov ↗ ← All trials in China