taVNS Effects on Fear Ratings in Naturalistic Context

Condition(s) studied

Investigational drug(s) / intervention(s)

transcutaneous auricular vagus nerve stimulation: Ear clip electrodes attached to the left cymba conchae to target vagus nerve branches.

Sham condition: Electrode placement attached on the left earlobe.

Study summary

During the fear rating task, 70 participants viewed a 600-second horror movie while continuously rating their subjective fear intensity (0-100 scale) every 0.51 seconds (1,170 total ratings). Functional near-infrared spectroscopy (fNIRS) data were simultaneously recorded using the NIRSIT LITE system to monitor cortical hemodynamic responses.

Eligibility

Primary outcome measure(s)

• Neural activity changes between groups — 10 minutes
  The differences in the activity of frontal regions between groups using fNIRS
• Fear ratings between groups — 10 minutes
  The differences in the fear ratings (0-100, from neutral to extremely fearful) between groups
• Functional connectivity witnin frontal regions between groups — 10 minutes
  The differences in the functional connectivity within frontal regions using fNIRS between groups
• The correlation between brain activity and behavioral ratings across groups — 10 minutes
  The correlation between brain activity and behavioral ratings across groups

Trial sites (1)

More University of Electronic Science and Technology of China trials in China

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