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Clinical Trials in China / NCT06975124
Recruiting Phase 1

taVNS Effects on Fear Ratings in Naturalistic Context

NCT06975124 · tracked via the Priya Life Science China tracker
Sponsor
University of Electronic Science and Technology of China
Phase
Phase 1
Started
2025-03-01
Last updated
2025-05-16

Condition(s) studied

Healthy Participants

Investigational drug(s) / intervention(s)

transcutaneous auricular vagus nerve stimulationSham condition

transcutaneous auricular vagus nerve stimulation: Ear clip electrodes attached to the left cymba conchae to target vagus nerve branches.

Sham condition: Electrode placement attached on the left earlobe.

Study summary

During the fear rating task, 70 participants viewed a 600-second horror movie while continuously rating their subjective fear intensity (0-100 scale) every 0.51 seconds (1,170 total ratings). Functional near-infrared spectroscopy (fNIRS) data were simultaneously recorded using the NIRSIT LITE system to monitor cortical hemodynamic responses.

Eligibility

Sex
ALL
Min age
18 Years
Max age
30 Years
Healthy volunteers
Accepted
Inclusion Criteria: Healthy participants without color blindness, current or regular substance or medication use, any current or history of medical or psychiatric disorders and contraindications for MRI. Exclusion Criteria: * Color blindness, * Current or regular substance or medication use * any current or history of medical or psychiatric disorders and contraindications for MRI

Primary outcome measure(s)

  • Neural activity changes between groups — 10 minutes
    The differences in the activity of frontal regions between groups using fNIRS
  • Fear ratings between groups — 10 minutes
    The differences in the fear ratings (0-100, from neutral to extremely fearful) between groups
  • Functional connectivity witnin frontal regions between groups — 10 minutes
    The differences in the functional connectivity within frontal regions using fNIRS between groups
  • The correlation between brain activity and behavioral ratings across groups — 10 minutes
    The correlation between brain activity and behavioral ratings across groups

Trial sites (1)

FacilityCityRegionStatus
Nirsit Lite Chengdu Sichuan Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06975124 on ClinicalTrials.gov ↗ ← All trials in China