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Regulatory · NICE technology appraisal guidance · England

NICE technology appraisals

Every medicine and treatment NICE has appraised for the NHS in England since 2000: NICE's recommendation, when it was published, whether it still stands, and a link to the guidance and to the medicine's trials on this site.

Source: NICE technology appraisal guidance and NICE's appraisal recommendations data, shown with NICE's permission. Checked 3 Oct 2026
1,189Technology appraisals published
90%Of 897 current decided appraisals recommend for at least some patients
72Published in 2026 so far
976Linked to a medicine page here
Maintained by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 — Top 14 finalist
Compiled from NICE technology appraisal guidance · Last verified · Editorial standards

NICE has published 1,189 technology appraisals since 2000, and 1,062 of them are still current. Of the current appraisals where NICE reached a decision, 90% recommend the medicine or treatment for at least some patients, including through the Cancer Drugs Fund. The most recent is TA1189, published 26 Aug 2026. NICE's decisions apply to the NHS in England; in Ireland the HSE decides on reimbursement, advised by the National Centre for Pharmacoeconomics.

01

What NICE decided

Appraisals by recommendation type
Recommended or optimised
836
Cancer Drugs Fund or Innovative Medicines Fund
64
Only in research
23
Not recommended
145
Terminated (no company submission)
177

An appraisal can contain several recommendations, for different groups of patients, so it can appear under more than one type. These explanations are ours; NICE's own definitions are on nice.org.uk.

02

Recommended or optimised

836 appraisals, newest first, page 2 of 9
AppraisalMedicine pageNICE recommendationPublishedStatus
Lisocabtagene maraleucel for treating relapsed or refractory large B-cell lymphoma after first-line chemoimmunotherapy when a stem cell transplant is suitable
NICE TA1048
Lisocabtagene maraleucelOptimised26 Mar 2025Current
12 SQ-HDM SLIT for treating allergic rhinitis and allergic asthma caused by house dust mites
NICE TA1045
—Optimised Not recommended5 Mar 2025
Updated 26 Aug 2026
Current
Osimertinib for adjuvant treatment of EGFR mutation-positive non-small-cell lung cancer after complete tumour resection
NICE TA1043
OsimertinibRecommended26 Feb 2025Current
Selpercatinib for previously treated RET fusion-positive advanced non-small-cell lung cancer
NICE TA1042
SelpercatinibOptimised19 Feb 2025Current
Durvalumab with etoposide and either carboplatin or cisplatin for untreated extensive-stage small-cell lung cancer
NICE TA1041
DurvalumabOptimised19 Feb 2025Current
Olaparib for treating BRCA mutation-positive HER2-negative advanced breast cancer after chemotherapy
NICE TA1040
OlaparibRecommended12 Feb 2025Current
Selpercatinib for advanced thyroid cancer with RET alterations untreated with a targeted cancer drug in people 12 years and over
NICE TA1039
SelpercatinibRecommended12 Feb 2025Current
Selpercatinib for advanced thyroid cancer with RET alterations after treatment with a targeted cancer drug in people 12 years and over
NICE TA1038
SelpercatinibOptimised12 Feb 2025Current
Pembrolizumab for adjuvant treatment of resected non-small-cell lung cancer
NICE TA1037
PembrolizumabRecommended5 Feb 2025Current
Elacestrant for treating oestrogen receptor-positive HER2-negative advanced breast cancer with an ESR1 mutation after endocrine treatment
NICE TA1036
ElacestrantOptimised5 Feb 2025Current
Vadadustat for treating symptomatic anaemia in adults having dialysis for chronic kidney disease
NICE TA1035
—Recommended23 Jan 2025Current
Anhydrous sodium thiosulfate for preventing hearing loss caused by cisplatin chemotherapy in people 1 month to 17 years with localised solid tumours
NICE TA1034
—Recommended22 Jan 2025Current
Vamorolone for treating Duchenne muscular dystrophy in people 4 years and over
NICE TA1031
VamoroloneRecommended16 Jan 2025Current
Durvalumab with chemotherapy before surgery (neoadjuvant) then alone after surgery (adjuvant) for treating resectable non-small-cell lung cancer
NICE TA1030
DurvalumabRecommended15 Jan 2025Current
Tebentafusp for treating advanced uveal melanoma
NICE TA1027
TebentafuspRecommended9 Jan 2025Current
Tirzepatide for managing overweight and obesity
NICE TA1026
TirzepatideOptimised23 Dec 2024
Updated 1 Sep 2025
Current
Ublituximab for treating relapsing multiple sclerosis
NICE TA1025
UblituximabOptimised18 Dec 2024Current
Bevacizumab gamma for treating wet age-related macular degeneration
NICE TA1022
—Recommended4 Dec 2024Current
Crizotinib for treating ROS1-positive advanced non-small-cell lung cancer
NICE TA1021
CrizotinibOptimised4 Dec 2024Current
Eplontersen for treating hereditary transthyretin-related amyloidosis
NICE TA1020
EplontersenRecommended27 Nov 2024Current
Crovalimab for treating paroxysmal nocturnal haemoglobinuria in people 12 years and over
NICE TA1019
CrovalimabRecommended20 Nov 2024Current
Fedratinib for treating disease-related splenomegaly or symptoms in myelofibrosis
NICE TA1018
FedratinibOptimised20 Nov 2024Current
Pembrolizumab with chemotherapy before surgery (neoadjuvant) then alone after surgery (adjuvant) for treating resectable non-small-cell lung cancer
NICE TA1017
PembrolizumabRecommended20 Nov 2024Current
Elafibranor for previously treated primary biliary cholangitis
NICE TA1016
ElafibranorRecommended14 Nov 2024Current
Teclistamab for treating relapsed and refractory multiple myeloma after 3 or more treatments
NICE TA1015
TeclistamabOptimised13 Nov 2024Current
Alectinib for adjuvant treatment of ALK-positive non-small-cell lung cancer
NICE TA1014
AlectinibRecommended13 Nov 2024Current
Quizartinib for induction, consolidation and maintenance treatment of newly diagnosed FLT3-ITD-positive acute myeloid leukaemia
NICE TA1013
QuizartinibRecommended23 Oct 2024Current
Avapritinib for treating advanced systemic mastocytosis
NICE TA1012
AvapritinibRecommended6 Nov 2024Current
Danicopan with ravulizumab or eculizumab for treating paroxysmal nocturnal haemoglobinuria
NICE TA1010
DanicopanOptimised23 Oct 2024Current
Latanoprost–netarsudil for previously treated primary open-angle glaucoma or ocular hypertension
NICE TA1009
—Optimised2 Oct 2024Current
Trifluridine–tipiracil with bevacizumab for treating metastatic colorectal cancer after 2 systemic treatments
NICE TA1008
—Recommended25 Sep 2024Current
Rucaparib for maintenance treatment of relapsed platinum-sensitive ovarian, fallopian tube or peritoneal cancer
NICE TA1007
RucaparibRecommended17 Sep 2024Current
Futibatinib for previously treated advanced cholangiocarcinoma with FGFR2 fusion or rearrangement
NICE TA1005
FutibatinibRecommended11 Sep 2024Current
Faricimab for treating visual impairment caused by macular oedema after retinal vein occlusion
NICE TA1004
FaricimabRecommended11 Sep 2024Current
Evinacumab for treating homozygous familial hypercholesterolaemia in people 12 years and over
NICE TA1002
—Recommended11 Sep 2024Current
Zanubrutinib for treating marginal zone lymphoma after anti-CD20-based treatment
NICE TA1001
ZanubrutinibRecommended4 Sep 2024Current
Iptacopan for treating paroxysmal nocturnal haemoglobinuria
NICE TA1000
IptacopanRecommended4 Sep 2024Current
Vibegron for treating symptoms of overactive bladder syndrome
NICE TA999
VibegronOptimised4 Sep 2024Current
Risankizumab for treating moderately to severely active ulcerative colitis
NICE TA998
RisankizumabOptimised22 Aug 2024Current
Pembrolizumab with platinum- and fluoropyrimidine-based chemotherapy for untreated advanced HER2-negative gastric or gastro-oesophageal junction adenocarcinoma
NICE TA997
PembrolizumabRecommended29 Aug 2024Current
Linzagolix for treating moderate to severe symptoms of uterine fibroids
NICE TA996
—Optimised14 Aug 2024Current
Relugolix for treating hormone-sensitive prostate cancer
NICE TA995
RelugolixRecommended14 Aug 2024Current
Burosumab for treating X-linked hypophosphataemia in adults
NICE TA993
—Recommended7 Aug 2024Current
Abaloparatide for treating osteoporosis after menopause
NICE TA991
—Optimised7 Aug 2024Current
Tenecteplase for treating acute ischaemic stroke
NICE TA990
TenecteplaseRecommended24 Jul 2024Current
Ivacaftor–tezacaftor–elexacaftor, tezacaftor–ivacaftor and lumacaftor–ivacaftor for treating cystic fibrosis
NICE TA988
Ivacaftor, TezacaftorRecommended24 Jul 2024Current
Lebrikizumab for treating moderate to severe atopic dermatitis in people 12 years and over
NICE TA986
LebrikizumabOptimised10 Jul 2024Current
Selective internal radiation therapy with QuiremSpheres for treating unresectable advanced hepatocellular carcinoma
NICE TA985
—Optimised3 Jul 2024Withdrawn
Tafamidis for treating transthyretin amyloidosis with cardiomyopathy
NICE TA984
—Recommended19 Jun 2024Current
Voxelotor for treating haemolytic anaemia caused by sickle cell disease
NICE TA981
—Optimised12 Jun 2024Current
Ivosidenib with azacitidine for untreated acute myeloid leukaemia with an IDH1 R132 mutation
NICE TA979
IvosidenibRecommended5 Jun 2024Current
Dabrafenib with trametinib for treating BRAF V600E mutation-positive glioma in children and young people aged 1 year and over
NICE TA977
DabrafenibRecommended29 May 2024Current
Tisagenlecleucel for treating relapsed or refractory B-cell acute lymphoblastic leukaemia in people 25 years and under
NICE TA975
TisagenlecleucelRecommended15 May 2024Current
Selinexor with bortezomib and dexamethasone for previously treated multiple myeloma
NICE TA974
SelinexorOptimised15 May 2024Current
Atogepant for preventing migraine
NICE TA973
AtogepantOptimised15 May 2024Current
Remdesivir and tixagevimab plus cilgavimab for treating COVID-19
NICE TA971
RemdesivirOptimised Not recommended8 May 2024Current
Selinexor with dexamethasone for treating relapsed and refractory multiple myeloma after 4 or more treatments
NICE TA970
SelinexorRecommended8 May 2024Current
Pembrolizumab for treating relapsed or refractory classical Hodgkin lymphoma in people 3 years and over
NICE TA967
PembrolizumabOptimised1 May 2024Current
Cabozantinib with nivolumab for untreated advanced renal cell carcinoma
NICE TA964
CabozantinibOptimised10 Apr 2024Current
Olaparib for maintenance treatment of BRCA mutation-positive advanced ovarian, fallopian tube or peritoneal cancer after response to first-line platinum-based chemotherapy
NICE TA962
OlaparibRecommended28 Mar 2024Current
Daratumumab in combination for treating newly diagnosed systemic amyloid light-chain amyloidosis
NICE TA959
DaratumumabOptimised27 Mar 2024Current
Ritlecitinib for treating severe alopecia areata in people 12 years and over
NICE TA958
RitlecitinibRecommended27 Mar 2024Current
Momelotinib for treating myelofibrosis-related splenomegaly or symptoms
NICE TA957
MomelotinibOptimised20 Mar 2024Current
Etrasimod for treating moderately to severely active ulcerative colitis in people aged 16 and over
NICE TA956
EtrasimodRecommended11 Mar 2024Current
Epcoritamab for treating relapsed or refractory diffuse large B-cell lymphoma after 2 or more systemic treatments
NICE TA954
EpcoritamabOptimised6 Mar 2024Current
Fluocinolone acetonide intravitreal implant for treating chronic diabetic macular oedema
NICE TA953
—Recommended13 Mar 2024Current
Talazoparib for treating HER2-negative advanced breast cancer with germline BRCA mutations
NICE TA952
TalazoparibRecommended21 Feb 2024Current
Olaparib with abiraterone for untreated hormone-relapsed metastatic prostate cancer
NICE TA951
OlaparibRecommended7 Feb 2024Current
Nivolumab–relatlimab for untreated unresectable or metastatic melanoma in people 12 years and over
NICE TA950
Nivolumab, RelatlimabOptimised7 Feb 2024Current
Belumosudil for treating chronic graft-versus-host disease after 2 or more systemic treatments in people 12 years and over
NICE TA949
BelumosudilRecommended7 Feb 2024Current
Ivosidenib for treating advanced cholangiocarcinoma with an IDH1 R132 mutation after 1 or more systemic treatments
NICE TA948
IvosidenibRecommended31 Jan 2024Current
Loncastuximab tesirine for treating relapsed or refractory diffuse large B-cell lymphoma and high-grade B-cell lymphoma after 2 or more systemic treatments
NICE TA947
Loncastuximab TesirineOptimised31 Jan 2024Current
Olaparib with bevacizumab for maintenance treatment of advanced high-grade epithelial ovarian, fallopian tube or primary peritoneal cancer
NICE TA946
OlaparibRecommended17 Jan 2024Current
Durvalumab with gemcitabine and cisplatin for treating unresectable or advanced biliary tract cancer
NICE TA944
DurvalumabRecommended10 Jan 2024Current
Hybrid closed loop systems for managing blood glucose levels in type 1 diabetes
NICE TA943
—Optimised19 Dec 2023Current
Empagliflozin for treating chronic kidney disease
NICE TA942
—Optimised20 Dec 2023Current
Pembrolizumab plus chemotherapy with or without bevacizumab for persistent, recurrent or metastatic cervical cancer
NICE TA939
PembrolizumabOptimised13 Dec 2023Current
Targeted-release budesonide for treating primary IgA nephropathy
NICE TA937
BudesonideOptimised20 Dec 2023
Updated 9 Oct 2025
Replaced by TA1128
Secukinumab for treating moderate to severe hidradenitis suppurativa
NICE TA935
SecukinumabOptimised6 Dec 2023Current
Foslevodopa–foscarbidopa for treating advanced Parkinson’s with motor symptoms
NICE TA934
—Optimised29 Nov 2023Current
Zanubrutinib for treating chronic lymphocytic leukaemia
NICE TA931
ZanubrutinibOptimised22 Nov 2023Current
Empagliflozin for treating chronic heart failure with preserved or mildly reduced ejection fraction
NICE TA929
—Recommended1 Nov 2023Current
Glofitamab for treating relapsed or refractory diffuse large B-cell lymphoma after 2 or more systemic treatments
NICE TA927
GlofitamabRecommended17 Oct 2023Current
Mirikizumab for treating moderately to severely active ulcerative colitis
NICE TA925
MirikizumabOptimised25 Oct 2023Current
Tirzepatide for treating type 2 diabetes
NICE TA924
TirzepatideOptimised25 Oct 2023
Updated 1 Sep 2025
Current
Daridorexant for treating long-term insomnia
NICE TA922
DaridorexantOptimised18 Oct 2023Current
Ruxolitinib for treating polycythaemia vera
NICE TA921
RuxolitinibRecommended18 Oct 2023Current
Tofacitinib for treating active ankylosing spondylitis
NICE TA920
TofacitinibOptimised18 Oct 2023Current
Rimegepant for treating migraine
NICE TA919
RimegepantOptimised18 Oct 2023Current
Bimekizumab for treating active ankylosing spondylitis and non-radiographic axial spondyloarthritis
NICE TA918
BimekizumabOptimised11 Oct 2023Current
Daratumumab with lenalidomide and dexamethasone for untreated multiple myeloma when a stem cell transplant is unsuitable
NICE TA917
DaratumumabRecommended25 Oct 2023Current
Bimekizumab for treating active psoriatic arthritis
NICE TA916
BimekizumabOptimised4 Oct 2023Current
Pegunigalsidase alfa for treating Fabry disease
NICE TA915
Pegunigalsidase-alfaRecommended4 Oct 2023Current
Pembrolizumab for previously treated endometrial, biliary, colorectal, gastric or small intestine cancer with high microsatellite instability or mismatch repair deficiency
NICE TA914
PembrolizumabOptimised20 Sep 2023Current
Mavacamten for treating symptomatic obstructive hypertrophic cardiomyopathy
NICE TA913
MavacamtenOptimised6 Sep 2023Current
Cipaglucosidase alfa with miglustat for treating late-onset Pompe disease
NICE TA912
Cipaglucosidase alfaRecommended15 Aug 2023Current
Olaparib for maintenance treatment of relapsed, platinum-sensitive ovarian, fallopian tube or peritoneal cancer after 2 or more courses of platinum-based chemotherapy
NICE TA908
OlaparibOptimised5 Jul 2023Current
Deucravacitinib for treating moderate to severe plaque psoriasis
NICE TA907
DeucravacitinibOptimised28 Jun 2023Current
Rimegepant for preventing migraine
NICE TA906
RimegepantOptimised5 Jul 2023Current
Upadacitinib for previously treated moderately to severely active Crohn’s disease
NICE TA905
UpadacitinibOptimised21 Jun 2023Current

Titles link to the guidance on nice.org.uk, where the full recommendations are. A medicine is linked to its page here only when the name NICE appraised is exactly the same molecule as ours; medicines given alongside it (“with chemotherapy”) are not counted as appraised. Appraisals of devices and procedures are listed but have no medicine page.

© NICE 2026 technology appraisal guidance. Available from www.nice.org.uk/guidance. All rights reserved. Subject to Notice of rights. NICE guidance is prepared for the National Health Service in England. All NICE guidance is subject to regular review and may be updated or withdrawn. NICE accepts no responsibility for the use of its content in this product/publication.

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How this page is built

NICE has allowed us to show the appraisal number, title, recommendation category and dates of each technology appraisal, with a link to the guidance. No guidance text is reproduced.

A nightly job reads NICE's recommendations data, reads each new appraisal page once and re-checks every page every 60 days for replaced or withdrawn guidance. It keeps the previous version if a refresh fails. No AI drafting. See our methodology. The NICE data on this page was last retrieved on 3 Oct 2026. How every register is built: methodology · fixes we have made: corrections log.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician — our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us — we correct promptly and log it.