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Priya Life Science Clinical trial register
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Clinical trial register · United States · industry-sponsored

HNSCC Trials in the USA, 2026

Every industry-sponsored study on the ClinicalTrials.gov registry that lists a US site and is open, about to open, active-but-closed, or enrolling by invitation. This deliberately excludes academic and other non-industry sponsors — the full US registry across all sponsors runs to over 22,000 recruiting studies alone.

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Source: ClinicalTrials.gov. Complete coverage of the industry-sponsored slice — all 9129 matching records are in this view (non-industry sponsors are out of scope by design, not truncated). Synced 03 Nov 2026, 03:16 UTC
9129
Studies in scope
industry-sponsored, all four open statuses
4971
Recruiting now
open to new participants
2191
Lead sponsors
across recruiting studies
Top states
California 6 Texas 6 Massachusetts 5 Missouri 4 Ohio 4
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Recruitment status
Phase
Target enrolment
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HNSCC trials in the USA

13 of 9129 studies
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Status
Study
Lead sponsor
Phase
Enrol
US states
Start
Not yet open
MTX-531-001 Phase 1 Study in Advanced Solid Tumors
NCT07874880Solid Tumors (Phase 1), HNSCC, Endometrial Cancer, Her2-negative Metastatic Breast Cancer
MEKanistic Therapeutics, Inc.
Phase 1
71
California
2026-10-20
Recruiting
TMV Vaccine Alone or With Toripalimab-tpzi for Recurrent Head and Neck Squamous Cell Carcinoma
NCT07898124Squamous Cell Carcinoma of Head and Neck, Squamous Cell Carcinoma of Head and Neck (SCCHN), HNSCC, Neoplasm Recurrence, Local
Metaclipse Therapeutics Corporation
Phase 1
30
Texas
2026-10-01
Recruiting
TwoStep Therapeutics, Inc.
Phase 1
74
Ohio, Oregon, Virginia
2026-09-02
Recruiting
A Phase 1 Study of NRM-823 in Participants With Locally Advanced or Metastatic Refractory Solid Tumors
NCT07182149HNSCC, ESCC, Esophageal Adenocarcinoma, Gastric Adenocarcinoma
Normunity AccelCo, Inc.
Phase 1
150
Colorado, Connecticut, District of Columbia, Massachusetts, Minnesota, Missouri, New Jersey, Ohio
2025-10-30
Recruiting
A First in Human Study of ALX2004 With Advanced or Metastatic Selected Solid Tumors
NCT07085091NSCLC (Advanced Non-small Cell Lung Cancer), HNSCC, CRC (Colorectal Cancer), ESCC
ALX Oncology Inc.
Phase 1
170
California, Florida, Michigan, New Jersey, Ohio, Oregon, Texas, Utah
2025-08-18
Recruiting
Intratumoral Delivery of Viral Replicon (saRNA) Particles Expressing IL-12 in Head and Neck Cancer
NCT06736379Head and Neck Cancers- Squamous Cell, Head and Neck Cancer, Solid Tumors, HNSCC
VLP Therapeutics
Phase 1
41
California
2025-05-13
Recruiting
A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients With Solid Tumors
NCT06789172Solid Tumours, Sarcoma, HNSCC, Non Small Cell Lung Cancer
Epkin
Phase 1
146
California, Texas
2025-01-23
Recruiting
First in Human Study of TUB-030 in Patients With Advanced Solid Tumors
NCT06657222Advanced Solid Tumors, HNSCC, SCLC, NSCLC
Gilead Sciences
Phase 1/2
250
Connecticut, Florida, Massachusetts, Minnesota, Missouri, New York, Ohio, Texas
2024-12-13
Recruiting
Adcendo ApS
Phase 1
210
Arkansas, Connecticut, Massachusetts, Missouri, New York, Texas
2024-11-25
Recruiting
CJ Bioscience, Inc.
Phase 1/2
160
California, Pennsylvania
2023-09-11
Active, closed
AgonOx, Inc.
Phase 1
18
Oregon
2023-06-19
Active, closed
Genentech, Inc.
Phase 1
165
California, Colorado, Florida, Georgia, Massachusetts, Missouri, New Jersey, Tennessee
2022-10-20
Recruiting
ImmVira Pharma Co. Ltd
Phase 1/2
30
Arizona, Massachusetts, Pennsylvania, Texas, Virginia
2020-09-17
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Cite this view

Priya Life Science (2026). Clinical trial register: industry-sponsored studies with a US investigative site, filtered. Derived from ClinicalTrials.gov. Retrieved 3 November 2026. https://priyalifescience.com/clinical-trials-usa/condition/hnscc

Query this register directly
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About this register

This register is built from ClinicalTrials.gov, the trial registry run by the U.S. National Library of Medicine. It includes every industry-sponsored study on the registry that lists at least one investigative site in the US and is recruiting, not yet recruiting, active but no longer recruiting, or enrolling by invitation: 9,129 studies in total at the last sync on 03 Nov 2026, 03:16 UTC. Academic and other non-industry sponsors are out of scope by design. The full list can be downloaded as CSV or queried as JSON through the register API.

This page shows the 13 of those studies listing the condition HNSCC.

How many HNSCC trials are recruiting in the US?

10 of the 13 studies on this page are recruiting new participants as of the 03 Nov 2026, 03:16 UTC sync. A further 1 have not yet opened recruitment, 2 are active but closed to new participants, and 0 are enrolling by invitation only. Eligibility for any study is decided by its study team.

Summary by phase

Studies by phase (HNSCC), 13 studies
PhaseStudiesRecruitingShare
Phase 110776.9%
Phase 1/23323.1%

Most active sponsors

Lead sponsors with the most studies (HNSCC)
Lead sponsorStudiesRecruiting
Adcendo ApS11
AgonOx, Inc.10
ALX Oncology Inc.11
CJ Bioscience, Inc.11
Epkin11
Genentech, Inc.10
Gilead Sciences11
ImmVira Pharma Co. Ltd11
MEKanistic Therapeutics, Inc.10
Metaclipse Therapeutics Corporation11

Top states

Top states (HNSCC), by number of studies with a site there
StateStudies
California6
Texas6
Massachusetts5
Missouri4
Ohio4
Connecticut3
Florida3
New Jersey3
Oregon3
Colorado2
Listing here is informational and not medical advice; eligibility is determined by each study team. Compare pay for the teams running these studies in the US Pharma Salary Guide, see who's behind them in the US Company Directory, or track approvals on the FDA Approvals Tracker. For Irish, UK and EU sites, see the Ireland, UK and EU registers.