A Study to Evaluate the Safety, Pharmacokinetics, and Activity of RO7566802 as a Single Agent and in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Solid Tumors
Condition(s) studied
Investigational drug(s) / intervention(s)
RO7566802: RO7566802 solution for infusion will be administered as specified in each treatment arm.
Atezolizumab: Atezolizumab solution for infusion will be administered as specified in each treatment arm.
Study summary
This is a first-in-human Phase I, open-label, dose-escalation and expansion study designed to evaluate the safety, tolerability, pharmacokinetics, immunogenicity, pharmacodynamic, and preliminary anti-tumor activity of RO7566802 as a single agent and in combination with atezolizumab in participants with locally advanced, recurrent, or metastatic incurable solid tumor malignancies. Participants will be enrolled in 2 stages: dose escalation and expansion.
Eligibility
Primary outcome measure(s)
- Number of Participants with Dose-limiting Toxicity (DLTs) — Cycle 1 Day 1 through 21 days after Cycle 2 Day 1 (Cycle length=21 days) (up to approximately 42 days)
- Percentage of Participants with Adverse Events (AEs) Determined According to National Cancer Institute Common Terminology Criteria for Adverse Events Version 5.0 (NCI CTCAE v5.0) — Up to approximately 4 years
Trial sites (18)
| Facility | City | Region | Status |
|---|---|---|---|
| University of Alabama at Birmingham (UAB) | Birmingham | Alabama | |
| Yale Cancer Center | New Haven | Connecticut | |
| Icahn School of Medicine at Mount Sinai (ISMMS) | New York | New York | |
| The Ohio State University | Columbus | Ohio | |
| Magee-Woman's Hospital | Harrisburg | Pennsylvania | |
| SCRI Oncology Partners | Nashville | Tennessee | |
| St Vincent's Hospital Sydney | Darlinghurst | New South Wales | |
| Peter Maccallum Cancer Centre | Melbourne | Victoria | |
| British Columbia Cancer Agency - 600 10th Ave W | Vancouver | British Columbia | |
| Princess Margaret Cancer Centre | Toronto | Ontario | |
| National University Hospital | Singapore | Singapore | |
| National Cancer Centre | Singapore | Singapore | |
| Addenbrooke's Hospital | Cambridge | United Kingdom | |
| Leicester Royal Infirmary | Leicester | United Kingdom | |
| St Bartholomew's Hospital | London | United Kingdom | |
| Sarah Cannon Research Institute | London | United Kingdom | |
| Churchill Hospital | Oxford | United Kingdom | |
| The Royal Marsden hospital | Sutton | United Kingdom |
On this site
📄 Tecentriq (atezolizumab) drug profile →More Genentech, Inc. trials in the UK
Other trials for the same condition
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT06031441 on ClinicalTrials.gov ↗ ← All trials in the UK