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Clinical Trials in Poland / NCT07027137
Active, not recruiting Not applicable

The Influence of Local Antibiotic Therapy on the Outcomes Following Periodontal Regeneration Procedures.

NCT07027137 · tracked via the Priya Life Science Poland tracker
Sponsor
Medical University of Bialystok
Phase
Not applicable
Started
2019-08-01
Last updated
2025-06-18

Condition(s) studied

PeriodontitisPeriodontal Diseases

Investigational drug(s) / intervention(s)

SRP+ANB+SURGSRP+SURG

SRP+ANB+SURG: SRP (scaling and root planing) with ANB (local antibiotic application- 10%doxycycline) and SURG (regeneration procedure according to MIST/M-MIST)

SRP+SURG: SRP (scaling and root planing) and SURG (regeneration procedure according to MIST/M-MIST)

Study summary

Assessmnet of the influence of local antibiotic therapy on the clinical, radiological, microbiological parameters and the inflammation mediators levels in the gingival crevicular fluid (GCF) following periodontal regeneration procedures in patients with periodontitis.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: -presence of an intrabony defect, with a pocket depth (PD) ≥ 6 mm and a radiological defect depth of ≥3 mm and width of ≥2 mm; Exclusion Criteria: * periodontal treatment within 3 months prior to the study; * antibiotic therapy within 3 months prior to the study; * smoking; presence of systemic diseases affecting periodontal healing, i.e.: immunosuppressive diseases, diabetes, osteoporosis, AIDS, hypertension treated with calcium channel blockers; * use of steroids or other immunosuppressive drugs; * pregnant and breastfeeding women

Primary outcome measure(s)

  • Assessment of the influence of local antibiotic therapy on the clinical, outcomes following periodontal regeneration procedures. — up to 12 months after treatment procedure
    PD (Pocket Depth) reduction- measured from the gingival margin to the bottom of the sulcus (mm) CAL (Clinical Attachment Level) gain- measured from the cemento-enamel junction to the bottom of the sulcus (mm)

Trial sites (1)

FacilityCityRegionStatus
Department of Integrated Dentistry, Medical University of Białystok Bialystok Podlaskie Voivodeship

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Other trials for the same condition

Evaluation Of The Efficacy Of Subgingival Application Of Lovastatin Gel As An Adjunct To Non-Surgical Treatment Of Periodontitis In Generally Healthy Smokers And Non-Smokers Patients in Central Europe. Recruiting
Evaluation of the Influence of PRF (Platelet-rich Fibrin) on the Clinical Parameters and the Concentration of Selected Inflammation Mediators in GCF (Gingival Crevice Fluid) of Patients With Periodontitis Active, not recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07027137 on ClinicalTrials.gov ↗ ← All trials in Poland