Neural Bases of Decision-making in Healthy Individuals

Condition(s) studied

Investigational drug(s) / intervention(s)

No intervention: No intervention

Study summary

The goal of this single center non-interventional fMRI study is to assess the neural bases of decision-making and executive functioning in healthy individuals,and whether/how their responsiveness is modulated by ageing. The main questions it aims to answer are:

1. are there specific neural correlates for ageing effects on executive functioning (particularly inhibitory control) and decision-making?
2. Is there a relationship, at the behavioral and neural levels, between ageing-related changes in executive functioning and decision-making?

Healthy participants will be recruited for

1. a behavioral assessment including multiple tests of decision-making and executive functioning/inhibitory control;
2. a fMRI session to collect data concerning a) brain activity associated with decision-making and executive functioning, b) brain structural morphometriy (grey-matter volume/density), and c) brain structural connectivity (diffusion weighted imaging).

Results will provide an useful baseline for investigating alterations of decision-making and executive functioning, and of their neural bases, in pathological conditions.

Eligibility

Primary outcome measure(s)

• Behavioral performance 1: Decision-making skills — MRI-acquisition day 1
  Participants' decision-making performance will be assessed in terms of "loss aversion" (i.e., the overweighting of potential losses compared with gains), after removing the potential confounding effect of risk aversion

Trial sites (1)

More Istituti Clinici Scientifici Maugeri SpA trials in Italy

Other trials for the same condition