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Clinical Trials in Italy / NCT05357768
Recruiting Observational

Global collaboRAtion on CIC-DUX4, BCOR-CCN3, High-grade Undifferentiated Round Cell Sarcoma (URCS) Project

NCT05357768 · tracked via the Priya Life Science Italy tracker
Sponsor
Istituto Ortopedico Rizzoli
Phase
Observational
Started
2019-06-11
Last updated
2025-05-30

Condition(s) studied

Undifferentiated Round Cell Sarcoma

Investigational drug(s) / intervention(s)

data collection and analysis on Formalin-fixed paraffin embedded tissue and/or frozen tumoral tissue

data collection and analysis on Formalin-fixed paraffin embedded tissue and/or frozen tumoral tissue: Formalin-fixed paraffin embedded tissue and/or frozen tumoral tissue of cases negative for all Ewing's sarcoma molecular fusions, will be analyzed for the presence of CIC-DUX4 / BCOR-CCNB3 translocations fusion at each Institution. Treatment, outcome, and prognostic factors will be related with the molecular re-classification.

Study summary

Experimental study with biological material : case series review of clinical and histological data

Eligibility

Sex
ALL
Min age
—
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Patients with undifferentiated round cell sarcomas treated from 01 January 1983 and all new patients will be included. * Clinical and outcome information available. * Histological slides/formalin-fixed paraffin-embedded tissue tumor blocks from archive available to perform the histology analysis/frozen tissue representative of the tumor available. Exclusion Criteria: * Diagnosis different from undifferentiated round cell sarcomas * Patient with no clinical or outcome information available

Primary outcome measure(s)

  • event free survival — baseline
    Correlate clinical and pathological variables with event-free survival and overall-survival in undifferentiated round cell sarcomas.

Trial sites (1)

FacilityCityRegionStatus
IRCCs Istituto Ortopedico Rizzoli Bologna BO Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05357768 on ClinicalTrials.gov ↗ ← All trials in Italy