Prospective Observational Cohort Study of Cardiac Structure and Function in Children and Adults With Osteogenesis Imperfecta

Condition(s) studied

Investigational drug(s) / intervention(s)

Imaging evaluation, Echocardiography: Since this is an observational study, researchers collect general information from instrumental investigations and functional assessments carried out as part of normal clinical practice

Study summary

This prospective observational investigation will examine the incidence and progression of cardiologic findings in individuals with OI across different age groups. Cardiopulmonary complications are recognized as major contributors to morbidity and mortality in adults with OI, although life expectancy has significantly improved in recent years due to medical advancements.

By systematically evaluating cardiovascular involvement in this population, the study aims to generate clinically relevant evidence to inform early cardiologic screening strategies and support the development of harmonized and targeted management approaches, ultimately improving clinical practice and the quality of life of individuals living with OI.

Eligibility

Primary outcome measure(s)

• Cardiac abnormalities — From enrollment to the end of study at 60 months
  The incidence of structural and functional cardiac abnormalities in individuals with osteogenesis imperfecta.

Trial sites (1)

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