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Clinical Trials in France / NCT07313098
Starting soon Observational

Longitudinal Assessment of Protein Markers in the Cerebrospinal Fluid of Patients With Central Nervous System Involvement

NCT07313098 · tracked via the Priya Life Science France tracker
Sponsor
Imagine Institute
Phase
Observational
Started
2027-01-01
Last updated
2026-09-09

Condition(s) studied

Neurologic DisorderCentral Nervous System Diseases

Study summary

In the context of adult pathology, research into biomarkers in cerebrospinal fluid (CSF) has already identified proteins that are commonly used for the early diagnosis of certain neurodegenerative diseases. However, the lack of data available in the literature on pediatric diseases has limited the use of biomarkers in routine practice in children. Importantly, our group has pioneered the establishment of CSF biomarkers in children (e.g., measurement of interferon alpha in CSF by ultra-sensitive digital ELISA), which will undoubtedly be used in routine clinical practice in the future. In light of these arguments, the establishment of a CSF biobank will have major clinical implications, given the rarity of the diseases treated and the number of patients followed.

Eligibility

Sex
ALL
Min age
—
Max age
—
Healthy volunteers
No
Inclusion Criteria: 1. Patients with a neurological condition diagnosed by a physician requiring cerebrospinal fluid (CSF) collection, through: * Neurosurgical procedure (EVD, VP shunt, VSG shunt, tumor surgery, spinal surgery with dural opening, ELD); * Lumbar puncture (LP). 2. Patients who have (or whose legal guardians, where applicable, have) consented to the storage and reuse of residual biological samples collected during the course of care within the biological collection. Exclusion Criteria: 1\. Objection by the patient and/or the legal guardian, if the patient is a minor, to participation in the study.

Primary outcome measure(s)

Trial sites (1)

FacilityCityRegionStatus
Hôpital Necker-Enfants malades Paris France

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07313098 on ClinicalTrials.gov ↗ ← All trials in France