functional magnetic resonance imaging: functional magnetic resonance imaging
Study summary
The obstructive sleep apnea syndrome (OSAS) involves recurrent sleep-related upper airways (UA) collapse. UA mechanical properties and neural control are altered, imposing a mechanical load on inspiration. UA collapse does not occur during wakefulness, hence arousal-dependent compensation. Experimental inspiratory loading in normal subjects elicits respiratory-related cortical activity during wakefulness. The objective of this study is to test whether awake OSAS patients would exhibit a similar cortical activity. Whether or not such cortical compensatory mechanisms have cognitive consequences would be also analyze.
Eligibility
Sex
ALL
Min age
18 Years
Max age
75 Years
Healthy volunteers
Accepted
Inclusion criteria :
1. OSAS patients
* severe OSAS with an Apnea-Hypopnea Index (AHI) \> 30/h
* without CPAP treatment
2. Non-OSAS patients
* absence of OSAS (AHI \< 15/h and absence of excessive daytime sleepiness with Epworth score \<11)
Non-inclusion criteria :
* \< 18 years old
* \>75 years old
* left-handed
* BMI\> 40 kg/m²
* another sleep disorder
* central component of sleep apnea syndrome (central apnea index\> 5 / h)
* current or past neurological pathology
* respiratory pathology (obstructive ventilatory disorder, restrictive ventilatory disorder, hypercapnia)
* MRI contraindication (metallic foreign body, claustrophobia, pregnant woman, etc.)
* taking drugs that can modify the BOLD signal on MRI (psychotropic drugs, vasodilators, vasoconstrictors, etc.),
* uncorrected sensory impairment (vision or hearing)
* protected by law.
Exclusion criteria :
* pregnant woman according to the positive beta-hCG test result
* left-handed following the laterality questionnaire
* MINI results showing:
* a current mood episode
* a current disorder of the use of psychoactive substances or in the last 6 months (excluding tobacco)
* an eating disorder
* a diagnosis of bipolar disorder, current or past schizophrenia
Primary outcome measure(s)
Premotor cortex activation in OSAS patients without CPAP — Day 0
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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