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Clinical Trials in France / NCT04253379
Recruiting Not applicable

Social Cognition in Pediatric Epilepsy

NCT04253379 · tracked via the Priya Life Science France tracker
Sponsor
CHU de Reims
Phase
Not applicable
Started
2020-02-02
Last updated
2025-09-22

Condition(s) studied

Pediatric Epilepsy

Investigational drug(s) / intervention(s)

Neuropsychological evaluation , Evaluation of theory of mind, Evaluation of executive functions, Evaluation of verbal skills

Neuropsychological evaluation , Evaluation of theory of mind, Evaluation of executive functions, Evaluation of verbal skills: Several tests will be used: Raven's Advanced Progressive Matrices, auditory attention subtest of the NEPSY II, Peabody Picture Vocabulary test, specific comprehension test The cognitive TOM will be evaluated with questions about 4 stories of false beliefs. The affective TOM will be evaluated with a specific emotion inference task 4 adapted subtests from several validated scales will be used to investigate inhibition, cognitive flexibility and working memory The semantic and pragmatic competences will be evaluated with 4 comprehension tasks.

Study summary

The purpose of this study is to investigate the development of social cognition skills in pediatric epilepsy compared to healthy children. There are evidences indicating that children with epilepsy have executive dysfunctions and language problems. Executive functions refer to multiple cognitive processes that contribute to human higher order abilities, such as purposeful and future-orientated behavior. Moreover, the literature regarding development of non epileptic children, with ordinary development indicates that executive functions and language are linked to the emergence of social cognition. Then, the investigators asked if children with epilepsy, as they commonly present executive dysfunctions, would show an atypical development of social cognition. Children with epilepsy and a control group of healthy volunteers will be compared to identify relationships between executive functions, language and social cognition.

Eligibility

Sex
ALL
Min age
6 Years
Max age
12 Years
Healthy volunteers
Accepted
Inclusion Criteria: * exposed children : children aged 6-12 with a diagnosis of epilepsy French native speaker * A control group of age-matched children who meet patient selection criteria with the exception of the epilepsy will also be sought Exclusion Criteria: * neurological or psychiatric disease in control group * Raven's Matrices score \< percentile 10

Primary outcome measure(s)

  • Social cognition evaluation — Day 0
    The cognitive theory of mind test The Cognitive Theory of mind will be evaluated with questions about 4 small stories of false beliefs. Number of items : 8 questions Minimum and Maximum values : 0-8 correct responses

Trial sites (1)

FacilityCityRegionStatus
Chu Reims Reims France Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT04253379 on ClinicalTrials.gov ↗ ← All trials in France