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Clinical Trials in France / NCT04563650
Active, not recruiting Not applicable

COVID-19 Serology and Immunosenescence

NCT04563650 · tracked via the Priya Life Science France tracker
Sponsor
Centre Hospitalier Universitaire, Amiens
Phase
Not applicable
Started
2020-08-29
Last updated
2026-06-15

Condition(s) studied

Covid19Geriatric MedicineSeroconversionImmunosenescence

Investigational drug(s) / intervention(s)

blood sample →

blood sample: Sample collection of 4 to 10 tubes of whole blood will be done according to centre Saint-Victor's protocol.

Study summary

This study aims to determine how long COVID-19 neutralizing antibodies can be detected in an elderly institutionalized population presenting fragility factors.

This study also aims to stratify seroconversion by immunological profiles of the elderly patients residing in the EHPAD. This stratification requires the measurement of immunological marker levels already described in immunosenescence and also involved in the development of certain chronic infectious diseases more common in the elderly population. This analysis will enable the investigators to describe an immunological, clinical and biological profile representing a patient who has developed an immunity against COVID 19. It will also help the investigators to understand the different mechanisms leading to a reduced immune response after a potential administration of a vaccine. Finally, it will help describe the immune profiles of elderly residents who presented with non-severe forms of COVID-19.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Residents of the EHPAD/USLD St Victor of the Amiens CHU who took part in the screening campaign (RT-PCR and serology) organized by the Amiens CHU * residents who signed a consent form to participate in the study Exclusion Criteria: * The patient or his legal representative refused to participate in the study * Heavily sedated patients

Primary outcome measure(s)

  • titers of COVID-19 neutralising antibodies — day 0
  • titers of COVID-19 neutralising antibodies — at 3 months
  • titers of COVID-19 neutralising antibodies — at 6 months
  • titers of COVID-19 neutralising antibodies — at 9 months

Trial sites (1)

FacilityCityRegionStatus
CHU Amiens Amiens France

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT04563650 on ClinicalTrials.gov ↗ ← All trials in France