Low Serum Creatinine as a Predictor of Prolonged Mechanical Ventilation and Weaning Failure

Condition(s) studied

Investigational drug(s) / intervention(s)

Dietary supplement creatine: Dietary supplement creatine. The dosage of creatine will be as follows: for the first 7 days after enrolment, the daily dose will be 2x5g. From days 8 to 21, the daily dose will be 1x5g. The substance will be administered orally or through a nasogastric tube.

Dietary supplement - placebo: Dietary supplement polydextrose as a placebo. The dosage of placebo will be as follows: for the first 7 days after enrolment, the daily dose will be 2x5g. From days 8 to 21, the daily dose will be 1x5g. The substance will be administered orally or through a nasogastric tube.

No intervention: Patients in Group 1 will serve as controls and will receive no intervention, only standard care.

Study summary

The main objective of the study is to determine whether a subnormal serum creatinine value upon admission to the Post-ICU Care Unit predicts the need for prolonged ventilatory support. A parallel objective of the study is to determine whether exogenous in-take of the dietary supplement creatine in patients with subnormal serum creatinine value is associated with a shortened duration of ventilatory support and improved patients outcome.

Eligibility

Primary outcome measure(s)

• Ventilator-free hours — 21 days
  The primary endpoint of the study will be the "ventilator-free hours", i.e. the total number of hours that the patient was without ventilator support

Trial sites (2)

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