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Clinical Trials in Czechia / NCT07374289
Recruiting Not applicable

On Scene ECPR in Ostrava

NCT07374289 · tracked via the Priya Life Science Czechia tracker
Sponsor
University Hospital Ostrava
Phase
Not applicable
Started
2026-01-30
Last updated
2026-01-30

Condition(s) studied

Cardiac Arrest (CA)Cardiogenic Shock

Investigational drug(s) / intervention(s)

Prehospital ECMO cannulation on scene of cardiac arrestTransfer with ongoing mechanical chest compression to hospital followed by hospital ECMO cannulation

Prehospital ECMO cannulation on scene of cardiac arrest: ECPR (Extracorporeal Cardiopulmonary Resuscitation) is a critical, advanced resuscitation technique using Veno-arterial Extracorporeal Membrane Oxygenation for patients in cardiac arrest where conventional CPR fails, functioning as a bridge to restore circulation and oxygenation by pumping and oxygenating blood outside the body before returning it.

Transfer with ongoing mechanical chest compression to hospital followed by hospital ECMO cannulation: ECPR (Extracorporeal Cardiopulmonary Resuscitation) is a critical, advanced resuscitation technique using Veno-arterial Extracorporeal Membrane Oxygenation for patients in cardiac arrest where conventional CPR fails, functioning as a bridge to restore circulation and oxygenation by pumping and oxygenating blood outside the body before returning it.

Study summary

On-scene extracorporeal pulmonary resuscitation (ECPR) for out-of-hospital cardiac arrest (OHCA) seems to speed up the start of extracorporeal membrane oxygenation (ECMO) and shorten low flow during cardiopulmonary resuscitation (CPR) in case of refractory cardiac arrest. The primary goal is to verify the benefit of on-scene ECPR in terms of shortening the collapse-to-ECMO interval. The secondary goal is to compare outcomes in the on-scene ECPR group with hospital cannulation.

Eligibility

Sex
ALL
Min age
18 Years
Max age
70 Years
Healthy volunteers
No
Inclusion Criteria: * Presumed cardiac aetiology of the cardiac arrest * Witnessed collapse * Bystander CPR * Estimated age ≤ 70 years * Body weight ≥15 Kg Exclusion Criteria: * Known terminal malignant disease * Known terminal chronic disease

Primary outcome measure(s)

  • Hospital survival — 30 days after the cardiac arrest
    Hospital survival will be assessed 30 days after the cardiac arrest
  • ICU stay — Through the ICU stay, on average 12 days
    The length of the Intensive Care Unit (ICU) stay will be assessed in days.
  • Neurologic outcomes — 30 days after the cardiac arrest
    Neurologic outcomes will be assessed in patients using the Cerebral Performance Category (CPC) score. The CPC score is a 1-to-5 scale assessing neurological outcome, most commonly after cardiac arrest, where 1 is best (normal brain function) and 5 is worst (brain death).

Trial sites (2)

FacilityCityRegionStatus
Emergency Medical Services, Moravian-Silesian Region Ostrava Moravian-Silesian Region Recruiting
University Hospital Ostrava Ostrava Moravian-Silesian Region Recruiting

More University Hospital Ostrava trials in Czechia

Optimization of Transport and Use of a Mobile ECMO Team in Patients With Sudden Cardiac Arrest in the Moravian-Silesian Region Recruiting
Prehospital ECPR in Moravia Silesia Region Recruiting
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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07374289 on ClinicalTrials.gov ↗ ← All trials in Czechia