Ireland
--:--IST
Latest
Astellas Expands Its 330 Million Euro Tralee Biopharma Facility with a Second Aseptic Filling Line to Double Drug-Product Capacity Xeolas Pharmaceuticals Opens 158,000 Sq Ft State-of-the-Art Baldoyle Facility to Scale Specialty Medicine Manufacturing Priya Life Science Partners with Fleming for the 9th Annual Corporate Compliance & Transparency in Life Sciences Summit in Zurich Ireland Has the Capital and the Lessons: Digital Project Management Is How They Become Delivery Dunbar Pharma Brings First Plant-Derived Dronabinol API to UK Market Through IPS Pharma Leveraging Priya Life Science as a Data Tracker: The Ultimate Use Case & Career Guide The €100K Reality Check: Why a Six-Figure Pharma Salary in Ireland Feels Different Than in Switzerland or Germany Ireland's €93.8 Billion Non-EU Pharma Export Engine: Trade Data, Destination Markets, and Economic Impact Astellas Expands Its 330 Million Euro Tralee Biopharma Facility with a Second Aseptic Filling Line to Double Drug-Product Capacity Xeolas Pharmaceuticals Opens 158,000 Sq Ft State-of-the-Art Baldoyle Facility to Scale Specialty Medicine Manufacturing Priya Life Science Partners with Fleming for the 9th Annual Corporate Compliance & Transparency in Life Sciences Summit in Zurich Ireland Has the Capital and the Lessons: Digital Project Management Is How They Become Delivery Dunbar Pharma Brings First Plant-Derived Dronabinol API to UK Market Through IPS Pharma Leveraging Priya Life Science as a Data Tracker: The Ultimate Use Case & Career Guide The €100K Reality Check: Why a Six-Figure Pharma Salary in Ireland Feels Different Than in Switzerland or Germany Ireland's €93.8 Billion Non-EU Pharma Export Engine: Trade Data, Destination Markets, and Economic Impact
Clinical Trials in Czechia / NCT06189924
Recruiting Observational

Exhaled Breath Condensate Analysis in Mechanically Ventilated Patients

NCT06189924 · tracked via the Priya Life Science Czechia tracker
Sponsor
The Institute of Molecular and Translational Medicine, Czech Republic
Phase
Observational
Started
2026-03-01
Last updated
2026-06-25

Condition(s) studied

Acute Respiratory FailureCritical Illness

Investigational drug(s) / intervention(s)

Proteomic analysis of exhaled breath condensate

Proteomic analysis of exhaled breath condensate: Mechanically ventilated intensive care patients will be sampled for exhaled breath condensate from the ventilator circuit.

Study summary

Mechanically ventilated intensive care patients will be sampled for a small amount of exhaled breath condensate from the ventilator circuit and for venous blood.

Proteomic analysis of the exhaled breath condensate will be performed using mass spectrometry and in the blood sample, corresponding changes in the DNA, RNA, proteins, and metabolites will be studied. Resulting profiles will be correlated with routinely monitored parameters in order to identify patterns corresponding to various pathologies in order to enable their early detection.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: Intensive care setting Mechanical ventilation Ventilator/ventilator circuit technically suitable for sampling of exhaled breath condensate Exclusion Criteria: Mechanical ventilation challenging to the extent that the insertion of the sampling kit into the ventilator circuit would substantially increase the risk for respiratory deterioration

Primary outcome measure(s)

  • Comparison of proteomic patterns of the exhaled breath condensate in mechanically ventilated intensive care patients. — January 2024 - December 2029
    Proteomic patterns of the exhaled breath condensate will be studied in mechanically ventilated intensive care patients. The results will be analysed and compared with the aim to identify patterns specific for the pathological conditions.

Trial sites (2)

FacilityCityRegionStatus
Institute of Molecular and Translational Medicine, Palacky University Olomouc Czechia Recruiting
University Hospital Olomouc Olomouc Czechia Recruiting

More The Institute of Molecular and Translational Medicine, Czech Republic trials in Czechia

The Effect of Multimodal Treatment of Rectal Cancer on Circulating Tumor Cells: A Prospective, Observational Study Recruiting
Study of Early Cancer Biomarkers in Breath Condensate in Population of Individuals With High-Risk of Lung Cancer Undergoing LDCT Screening. Recruiting
Biomarkers of Endometrial Receptivity Recruiting
Self-sampling for Non-attenders to Cervical Cancer Screening Recruiting
Assesment of Multiomics Profiles in Health and Disease. Recruiting

Other trials for the same condition

Reduction of Muscle Catabolism Through Brain Activation in Burn Patients Starting soon
Low Serum Creatinine as a Predictor of Prolonged Mechanical Ventilation and Weaning Failure Recruiting
Hyperinflammation and Hyperferritinemia in Critically Ill Patients Starting soon
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06189924 on ClinicalTrials.gov ↗ ← All trials in Czechia