Bidirectional Cohort Study of a Prognosis Model for Acute-on-chronic Liver Failure

NCT07548190 · tracked via the Priya Life Science China tracker

Sponsor

The Second Affiliated Hospital of Chongqing Medical University

Phase

Observational

Started

2018-01-01

Last updated

2026-04-23

Condition(s) studied

Liver Failure

Study summary

This study constitutes a bidirectional cohort investigation. By collating laboratory parameters and clinical data-including plasma and peripheral blood mononuclear cell (PBMC) analyses-from patients with acute-on-chronic liver failure, it aims to provide a reference framework for predicting prognosis and the occurrence of complications.

Eligibility

Sex

ALL

Min age

18 Years

Max age

85 Years

Healthy volunteers

Inclusion Criteria: •Clinical diagnosis of Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) Exclusion Criteria: * age \< 18 years * extrahepatic organ failure unrelated to ACLF * active malignancy * co-infection with other hepatitis viruses or human immunodeficiency virus (HIV) * prior liver transplantation * use of immunosuppressants within 6 months before enrollment * unclear history of antiviral therapy

Primary outcome measure(s)

Primary endpoint was all-cause mortality at days 28, 90, 180, and 360. — Days 28, 90, 180, and 360

Trial sites (1)

Facility	City	Region	Status
Department of Infectious Diseases, Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, The Second Affiliated Hospital, Chongqing Medical University	Chongqing	China

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07548190 on ClinicalTrials.gov ↗ ← All trials in China