Establishment and Evaluation of Prenatal Prevention and Treatment Strategy for NARDS

Condition(s) studied

Investigational drug(s) / intervention(s)

Dexamethasone: ACS intervention were used in the experimental group

Study summary

1. A predictive model for NARDS was established based on perinatal risk factors. Multivariate Logistic regression analysis was used to screen the independent prenatal risk factors for NARDS. A Logistic regression model was constructed using the above independent risk factors and quantified in a nomogram to construct a visualization model for prenatal prediction of NARDS.
2. The role of ACS in the prevention and treatment of ARDS in near-term/full-term infants.

For neonates with a probability greater than 80% in the prediction model of ARDS, at least one ACS was given before the termination of pregnancy. The GC level of cord blood (taken at birth) and the mRNA levels of α-ENaC, Na-K-atpase and SGK1 in nasal epithelium were measured within 2 hours and 1 day after birth in the ACS intervention group and the control group. The occurrence and severity of pulmonary edema, the occurrence and severity of ARDS, and the mortality rate of NARDS were evaluated by lung ultrasound. The indexes of the two groups were compared horizontally and longitudinally.

Eligibility

Primary outcome measure(s)

• The incidence and severity of neonatal acute respiratory distress syndrome — 1 year
  The incidence and severity of neonatal acute respiratory distress syndrome will be compared between the two groups
• The incidence and severity of pulmonary edema — 1 year
  The incidence and severity of pulmonary edema will be compared between the two groups
• The mortality of NARDS — 1 year
  The mortality rate of NARDS will be compared between the two groups
• The mRNA levels of α-ENaC, Na-K-atpase, and SGK1 in nasal epithelium — Day 0 after birth
  The mRNA levels of α-ENaC, Na-K-atpase, and SGK1 in nasal epithelium will be compared between the two groups
• The glucocorticoid level in cord blood — Day 0 after birth
  The glucocorticoid levels of cord blood will be compared between the two groups

Trial sites (1)

More The Second Affiliated Hospital of Chongqing Medical University trials in China

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