The Physiological Effect of RCexp on Ventilation/Perfusion Distribution

NCT06919484 · tracked via the Priya Life Science China tracker

Sponsor

Southeast University, China

Phase

Observational

Started

2025-11-30

Last updated

2025-11-26

Condition(s) studied

Acute Respiratory Distress SyndromeMechanical Ventilation

Investigational drug(s) / intervention(s)

RCexp

RCexp: patients received different RCexp

Study summary

With the exception of setting the positive end-expiratory pressure (PEEP), the expiratory phase is commonly overlooked during MV. The expiratory time constant (RCexp) plays an important role in understanding the mechanical properties of the respiratory system in patients receiving mechanical ventilation. However, it is unclear that the effect of expiratory time constant on the ventilation and perfusion distribution.

Eligibility

Sex

ALL

Min age

19 Years

Max age

—

Healthy volunteers

Inclusion Criteria: adult patients with ARDS receiving mechanical ventilation no more than 72 hours Exclusion Criteria: 1. age \<18 years old 2. patient undergoing legal protection 3. contra-indications to EIT (e. g. severe chest trauma or wounds) 4. pneumothorax 5. patient undergoing ECMO 6. pregnancy

Primary outcome measure(s)

Difference in ventilation/perfusion mismatch — 4 hours
ventilation/perfusion mismatch is measured by EIT

Trial sites (1)

Facility	City	Region	Status
Zhongda Hospital, School of Medicine, Southeast University	Nanjing	Jiangsu	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06919484 on ClinicalTrials.gov ↗ ← All trials in China