The Second Affiliated Hospital of Chongqing Medical University
Phase
Observational
Started
2024-12-09
Last updated
2026-02-09
Condition(s) studied
Lung NeoplasmsRadiation Pneumonitis
Study summary
This retrospective single-center study investigates whether four-dimensional CT (4DCT)-based lung ventilation imaging can guide functional lung avoidance radiotherapy (FLAR) for patients with primary lung cancer.
Ventilation maps generated from planning 4DCT are used to identify well-ventilated lung regions, enabling paired comparison between functional lung avoidance radiotherapy plans and conventional anatomic radiotherapy plans.
The study aims to assess whether incorporating functional lung information into radiotherapy planning can reduce radiation exposure to well-ventilated lung while maintaining adequate tumor coverage, and to explore its relationship with radiation-induced lung injury.
All analyses are based on existing clinical imaging, treatment planning data, and follow-up records. No additional interventions, imaging, or procedures are performed as part of this study.
Eligibility
Sex
ALL
Min age
18 Years
Max age
85 Years
Healthy volunteers
No
Inclusion Criteria:
* Histologically confirmed primary lung cancer (adenocarcinoma, squamous cell carcinoma, or small-cell carcinoma) treated with thoracic radiotherapy.
* High-quality 4DCT scans performed before radiotherapy, enabling generation of ventilation or perfusion maps.
* Radiotherapy plans designed using IMRT.
* Availability of both functional lung avoidance plans and conventional anatomical radiotherapy plans for paired analysis.
* Complete treatment and follow-up records, including radiation-induced lung injury (e.g., radiation pneumonitis) and pulmonary function tests.
Exclusion Criteria:
* Incomplete or poor-quality imaging data preventing accurate ventilation/perfusion map generation.
* Radiotherapy interrupted or incomplete for any reason.
* Severe underlying lung diseases (e.g., extensive emphysema, pulmonary fibrosis, active tuberculosis) that may confound treatment outcomes or toxicity assessment.
* Presence of other untreated primary malignancies during the study period.
* Prior lung surgery or local therapies (e.g., ablation) that may affect evaluation of radiation-induced lung injury.
* Missing follow-up data, making assessment of radiation-induced lung injury or long-term lung function changes impossible.
Primary outcome measure(s)
Incidence of Radiation-Induced Lung Injury (Grade ≥2) — Assessed at 3 months, 6 months, and 12 months after completion of radiotherapy. Incidence of radiation-induced lung injury (RILI) of Grade ≥ 2, assessed using the Common Terminology Criteria for Adverse Events (CTCAE), Version 5.0.
CTCAE grades range from Grade 1 (mild) to Grade 5 (death related to adverse event), with higher grades indicating more severe toxicity.
The primary outcome is the proportion of patients experiencing CTCAE Grade ≥ 2 RILI.
Trial sites (1)
Facility
City
Region
Status
Cancer Center, Second Affiliated Hospital of Chongqing Medical University
Chongqing
China
More The Second Affiliated Hospital of Chongqing Medical University trials in China
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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