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Clinical Trials in China / NCT07504731
Recruiting Observational

Trunk Inclination, Positive End-expiratory Pressure, and Lung Recruitability

NCT07504731 · tracked via the Priya Life Science China tracker
Sponsor
Zhongda Hospital
Phase
Observational
Started
2026-03-20
Last updated
2026-09-03

Condition(s) studied

Acute Respiratory Distress Syndrome (ARDS)

Investigational drug(s) / intervention(s)

Specific lung recruitment maneuvers and decremental PEEP steps

Specific lung recruitment maneuvers and decremental PEEP steps: Specific lung recruitment maneuvers will be performed to measure the potential for lung recruitment. Followed by a decremental PEEP steps to determine lung mechanics at different PEEP levels. These process will be repeated when patients change to another position. Electrical impedance tomography signals, synchronized signals of airway pressure and flow, esophageal pressure will be recorded continuously.

Study summary

This multicenter, physiological, observational study hypothesizes that in moderate to severe ARDS, trunk inclination unloads the chest wall, but its impact on lung mechanics depends on PEEP levels and lung recruitability.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Intubated moderate and severe ARDS according to the Berlin definition (PaO2/FiO2 ratio \<= 200 mmHg) * Under continuous sedation with or without paralysis Exclusion Criteria: * Age \<18 years * Bronchopleural fistula * Pure COPD exacerbation * Contraindication to EIT monitoring (e.g. burns, pacemaker, thoracic wounds limiting electrode belt placement) * Hemodynamic instability (Systolic BP \< 75 mmHg or MAP \< 60 mmHg despite vasopressors and/or heart rate \< 55 bpm) * Contraindications to mobilization (e.g., intracranial hypertension, spinal cord injury) * Intra-abdominal hypotension (IAP≥12mmHg) * Pregnancy * Attending physician deems the transient application of high airway pressures to be unsafe

Primary outcome measure(s)

  • Transpulmonary driving pressure (ΔPL) — 2 hour
    Physiological parameter calculated as end-inspiratory transpulmonary pressure minus end-expiratory transpulmonary pressure. Transpulmonary pressure is monitored continuously in real time using an esophageal balloon catheter.

Trial sites (3)

FacilityCityRegionStatus
Zhongda Hospital, Southeast University Nanjing Jiangsu Recruiting
The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital Jinan Shandong Recruiting
West China Hospital of Sichuan University Chengdu Sichuan Not Yet Recruiting

More Zhongda Hospital trials in China

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Efficacy Analysis of Saccharomyces Boulardii Combined With Minocycline in Treatment-naïve Patients With Helicobacter Pylori Infection Starting soon
Effect of Roxadustat on Heart Failure Patients With Anaemia and Moderate-to-Severe Chronic Kidney Disease Starting soon
A Multicenter Prospective Study on the Performance of Spectral CT for Evaluating Treatment Response After TACE in Hepatocellular Carcinoma Recruiting

Other trials for the same condition

To Evaluate The Safety and Efficacy of STSA-1002 Injection in Patients With Acute Respiratory Distress Syndrome Recruiting
Electrical Impedance Tomography-Based Prognostic Model for ARDS Recruiting
Early EIT-Guided PEEP Titration on Pulmonary Physiology in Patients With Moderate-to-Severe ARDS Undergoing Prone Positioning (EIT-PEEP-PRONE) Starting soon
The Feasibility of Pulmonary Perfusion Assessment Using Sodium Bicarbonate Contrast With Electrical Impedance Tomography: A Prospective Pilot Study Recruiting
Dexamethasone Treatment for Sepsis-associated Acute Respiratory Distress Syndrome: a Multicenter, Randomised, Double-blinded, Controlled Trial Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07504731 on ClinicalTrials.gov ↗ ← All trials in China