Efficacy Analysis of Saccharomyces Boulardii Combined With Minocycline in Treatment-naïve Patients With Helicobacter Pylori Infection

Inclusion Criteria: 1. Aged 18-70 years, regardless of gender; 2. Positive 13C/14C urea breath test result; 3. No previous history of H. pylori eradication treatment; 4. Agreement to participate in this study and signing of the informed consent form. Exclusion Criteria: 1. History of ≥ 1 instance of failed H. pylori eradication; 2. Use of antibiotics (including antibacterial traditional Chinese medicines), nonsteroidal anti-inflammatory drugs (NSAIDS), bismuth agents, H2 receptor antagonists (H2RAs), proton-pump inhibitors (PPIs), and potassium-competitive acid blockers (P-CAB) within 4 weeks before treatment; 3. Plans to conceive, pregnancy, or breastfeeding; 4. Severe liver, kidney, or cardiovascular diseases; malignancies; and alcoholism; 5. Allergies to the drugs used in this study or a history of penicillin allergy; 6. The inability to correctly express one's symptoms and wishes, such as inability due to mental illness or severe neurosis.