Protective Effect of CoQ10 Against Negative Inflammatory Response and Organ Dysfunction in Cardiovascular Surgery (PANDA V)

Condition(s) studied

Investigational drug(s) / intervention(s)

Coenzyme Q10: Coenzyme Q10 is a cardiovascular health supplement. It is a component of the electron transport chain and participates in aerobic cellular respiration, which generates energy in the form of ATP. The ingredients in Coenzyme Q10 help regulate the body's production of free radicals, strengthen the arteries and heart, and reverse oxidation.

Standard Medical Therapy: Patients only received standard medical therapy without CoQ10.

Study summary

Cardiovascular diseases are the leading causes of death and prescription drug use. Research on certain dietary supplements looks promising as a way to help reduce risk factors. Previous studies showed that CoQ10 levels were decreased in cardiovascular patients and worsening of mitochondrial dysfunction was observed. The overall objective of this study is to determine if supplementing with CoQ10 can reduce inflammatory risk factors in adults with cardiac surgery, independent of other dietary or physical activity changes.

Eligibility

Primary outcome measure(s)

• C-reactive protein — Change from baseline of CRP in mg/L at 5 days after surgery.
  Inflammatory and endothelial blood work biomarkers

Trial sites (4)

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