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Clinical Trials in China / NCT04444362
Enrolling by invitation Not applicable

Protective Effect of Probacine Against Negative Gut Metabolism and Organ Dysfunction After Cardiovascular Surgery (PANDA IV)

NCT04444362 · tracked via the Priya Life Science China tracker
Sponsor
Nanjing Medical University
Phase
Not applicable
Started
2025-01-01
Last updated
2026-01-06

Condition(s) studied

Cardiovascular DiseaseCardiopulmonary Bypass

Investigational drug(s) / intervention(s)

Intestinal Microbiota Transplant (IMT) Capsules

Intestinal Microbiota Transplant (IMT) Capsules: Intestinal Microbiota Transplant (IMT) Capsules were administered 7 days preoperatively and 14 days postoperatively.

Study summary

Cardiovascular diseases (CVDs) continue to be the primary cause of illness and death globally, emphasizing the pressing requirement for efficient prevention methods. Recent studies indicate that the gut microbiome plays a vital role in maintaining cardiovascular health, affecting the pathophysiological mechanisms related to CVDs. The potential therapeutic strategies for primary care practitioners included the modulation of the gut microbiome through dietary changes, prebiotics, and probiotics. The aim of this study was to investage the effect of gut microbiome modulation on clinical outcomes after cardiac surgery.

Eligibility

Sex
ALL
Min age
18 Years
Max age
90 Years
Healthy volunteers
No
Inclusion Criteria: * Adult men and women; * Cardiovascular surgery; * Agree to participate in the study and sign the informed consent form. Exclusion Criteria: * Pregnant women; * Patients with preexisting psychotic disorders; * Decline to participate in the study.

Primary outcome measure(s)

  • Acute Gastrointestinal Injury — 14 days after surgery

Trial sites (5)

FacilityCityRegionStatus
Beijing Anzhen Hospital Beijing Beijing Municipality
The First Affiliated Hospital of Guangzhou Medical University Guangzhou Guangdong
The First Affiliated Hospital of Nanjing Medical University Nanjing Jiangsu
West China Hospital of Sichuan University Chengdu Sichuan
Shanghai East Hospital, Tongji University Shanghai China

More Nanjing Medical University trials in China

Recurrent Liver Cancer: Reconceptualization and Reevaluation Recruiting
Exercise and Mindfulness Intervention for Chemotherapy-Induced Peripheral Neuropathy in Patients With Cancer Active, not recruiting
Open-Label Study of Dimethyl Fumarate in Adults With Type 1 Diabetes Recruiting
Health Behavior Intervention for Colorectal Cancer Patients Starting soon
Effects and Mechanisms of Transcranial Direct Current Stimulation Combined With Dialectical Behavior Therapy Skills Training in Adults With Attention-Deficit/Hyperactivity Disorder Recruiting

Other trials for the same condition

rhBNP for Prevention of Cardiac Surgery-Associated Acute Kidney Injury (CSA-AKI) Starting soon
Nitric Oxide for Reduced Intensive Support in Cardiac Surgery With Cardiopulmonary Bypass Recruiting
Olpasiran Trials of Cardiovascular Events and Lipoprotein(a) Reduction - Coronary Computed Tomography Angiography Trial Recruiting
Cardiovascular Disease Cohort in Guangdong Province Active, not recruiting
Research on Circulation Management Strategy Based on Oxygen Metabolism Balance After CHD Surgery Enrolling by invitation
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT04444362 on ClinicalTrials.gov ↗ ← All trials in China