Protective Effect of Probacine Against Negative Gut Metabolism and Organ Dysfunction After Cardiovascular Surgery (PANDA IV)

NCT04444362 · tracked via the Priya Life Science China tracker

Sponsor

Nanjing Medical University

Phase

Not applicable

Started

2025-01-01

Last updated

2026-01-06

Condition(s) studied

Cardiovascular DiseaseCardiopulmonary Bypass

Investigational drug(s) / intervention(s)

Intestinal Microbiota Transplant (IMT) Capsules

Intestinal Microbiota Transplant (IMT) Capsules: Intestinal Microbiota Transplant (IMT) Capsules were administered 7 days preoperatively and 14 days postoperatively.

Study summary

Cardiovascular diseases (CVDs) continue to be the primary cause of illness and death globally, emphasizing the pressing requirement for efficient prevention methods. Recent studies indicate that the gut microbiome plays a vital role in maintaining cardiovascular health, affecting the pathophysiological mechanisms related to CVDs. The potential therapeutic strategies for primary care practitioners included the modulation of the gut microbiome through dietary changes, prebiotics, and probiotics. The aim of this study was to investage the effect of gut microbiome modulation on clinical outcomes after cardiac surgery.

Eligibility

Sex

ALL

Min age

18 Years

Max age

90 Years

Healthy volunteers

Inclusion Criteria: * Adult men and women; * Cardiovascular surgery; * Agree to participate in the study and sign the informed consent form. Exclusion Criteria: * Pregnant women; * Patients with preexisting psychotic disorders; * Decline to participate in the study.

Primary outcome measure(s)

Acute Gastrointestinal Injury — 14 days after surgery

Trial sites (5)

Facility	City	Region
Beijing Anzhen Hospital	Beijing	Beijing Municipality
The First Affiliated Hospital of Guangzhou Medical University	Guangzhou	Guangdong
The First Affiliated Hospital of Nanjing Medical University	Nanjing	Jiangsu
West China Hospital of Sichuan University	Chengdu	Sichuan
Shanghai East Hospital, Tongji University	Shanghai	China

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT04444362 on ClinicalTrials.gov ↗ ← All trials in China