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Clinical Trials in China / NCT03331133
Recruiting Observational

Twins Born in Guangzhou

NCT03331133 · tracked via the Priya Life Science China tracker
Sponsor
Guangzhou Women and Children's Medical Center
Phase
Observational
Started
2012-02-01
Last updated
2024-02-26

Condition(s) studied

Twin DiseasesImmune DevelopmentChildhood ObesityHost and MicrobiomeNeurodevelopment

Investigational drug(s) / intervention(s)

No intervention

Study summary

The 2-BIG is a twin birth cohort study located in Guangzhou, China.Its initial aim is to facilitate research on understanding the interplay between genes and environmental factors on disease etiology. Data are collected regarding environmental, family and lifestyle exposures on twins from birth to 18 years old. Biological samples including blood and tissue samples are also collected from the twins and their parents.

Eligibility

Sex
ALL
Min age
—
Max age
18 Years
Healthy volunteers
Accepted
Inclusion Criteria: 1. Live twins delivered in Guangzhou Women and Children's Medical Center 2. Permanent residents or families intended to remain in Guangzhou with their children for no less than 3 years 3. Baseline information during pregnancy available

Primary outcome measure(s)

  • Neurodevelopment at early childhood — At age of 1 year old
    Including adaptive, gross motor, fine motor, language, and social function; assessed using Gesell Developmental Schedules.
  • Intelligence quotient — At age of 6 years old
    Assessed using the Wechsler Preschool and Primary Scale of Intelligence-Fourth Edition including 5 verbal and 3 performance subtests. Intelligence quotient ranges 40-160, in which under 70 is defined as mental retardation. The total score was calculated by an online system.
  • Change of gene expression during childhood — Age at 1 year , 6 years, 12years and 18years
    DNA methylation, histone acetylation etc. assessed by analyses of blood samples

Trial sites (1)

FacilityCityRegionStatus
Guangzhou Women and Children's Medical Center Guangzhou Guangdong Recruiting

More Guangzhou Women and Children's Medical Center trials in China

The Born in Guangzhou Cohort Study (BIGCS) Recruiting
Diagnosis and Management of Intrauterine Growth Restriction and Congenital Anomalies Recruiting
CD19/CD22 CAR-T Cell Therapy in MRD-Positive B-lineage Acute Lymphoblastic Leukemia in Children. Recruiting
Non-Helium Magnetoencephalography in Pediatric Refractory Epilepsy Recruiting
Offspring Born to Mothers With Polycystic Ovary Syndrome in Guangzhou Cohort Study Recruiting

Other trials for the same condition

The Born in Guangzhou Cohort Study (BIGCS) Recruiting
Time Restricted Eating in Childhood Obesity (TRECO) Recruiting
Maternal Grandmothers in the Born in Guangzhou Cohort Study Recruiting
IVF Offspring Born in Guangzhou Recruiting
Optimizing Intervention Effects in Children and Adolescents Active, not recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT03331133 on ClinicalTrials.gov ↗ ← All trials in China