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Trackers› Clinical trials› Canada
Clinical trial register · Canada

Studies with a Canadian investigative site

Every study on the ClinicalTrials.gov registry that lists a site in Canada and is open, about to open, active-but-closed, or enrolling by invitation. Filter it, cite it, and take it away as a file.

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Source: ClinicalTrials.gov, U.S. National Library of Medicine. Complete coverage — all 6540 matching records held by the registry are in this view. Synced 26 Sep 2026, 19:55 UTC
6540
Studies in scope
all four open statuses
3515
Recruiting now
open to new participants
887
Lead sponsors
across recruiting studies
Top sites
Toronto 2809 Montreal 1902 Vancouver 1179 Calgary 1061 Edmonton 1017
Narrow the register
Recruitment status
Phase
Lead sponsor
University Health Network, Toronto349 University of British Columbia197 AstraZeneca190 University of Alberta180 University of Calgary149
Site location
Toronto2809 Montreal1902 Vancouver1179 Calgary1061 Edmonton1017
All 255 locations
Target enrolment
to

Trials in this register

6540 of 6540 studies
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Status
Study
Lead sponsor
Phase
Enrol
Sites in Canada
Start
Active, closed
REDAPT Revision Hip System With RSA
NCT04541693Hip Osteoarthritis
Orthopaedic Innovation Centre
Not applicable
8
Winnipeg
2019-01-15
Recruiting
Cardiac Sarcoidosis Randomized Trial
NCT03593759Cardiac Sarcoidosis, Sarcoidosis
DrugsPrednisolone·Methotrexate·Prednisone
Ottawa Heart Institute Research Corporation
Phase 3
160
Calgary, Vancouver, St. John's, Halifax, Hamilton, London, Ottawa, Montreal
2019-01-15
Active, closed
A Registry for Patients With Multifocal Ground Glass Opacities (GGOs)
NCT03802981Multiple Ground Glass Opacities (GGOs)
Memorial Sloan Kettering Cancer Center
Observational
338
Hamilton, Toronto, Montreal
2019-01-09
Active, closed
Long-term Safety and Efficacy Study of Fitusiran in Patients With Hemophilia A or B, With or Without Inhibitory Antibodies to Factor VIII or IX
NCT03754790Hemophilia
DrugFitusiran
Genzyme, a Sanofi Company
Phase 3
281
Montreal
2019-01-09
Active, closed
Osimertinib Plus Savolitinib in EGFRm+/MET+ NSCLC Following Prior Osimertinib
NCT03778229Carcinoma
DrugsSavolitinib·Osimertinib
AstraZeneca
Phase 2
367
Calgary, Edmonton, Newmarket, North York, Toronto
2019-01-09
Active, closed
Durvalumab Treatment in Combination With Chemotherapy and Bevacizumab, Followed by Maintenance Durvalumab, Bevacizumab and Olaparib Treatment in Advanced Ovarian Cancer Patients
NCT03737643Advanced Ovarian Cancer
DrugsOlaparib·Durvalumab·Bevacizumab·Paclitaxel
AstraZeneca
Phase 3
1,407
Calgary, Barrie, Greater Sudbury, Toronto, Montreal, Québec, Rimouski
2019-01-04
Active, closed
9-ING-41 in Patients With Advanced Cancers
NCT03678883Cancer, Pancreatic Cancer, Sarcoma, Renal Cancer
DrugsLomustine·Doxorubicin·Irinotecan·Nab-paclitaxel
Actuate Therapeutics Inc.
Phase 2
350
Edmonton, Halifax, Greenfield Park, Montreal, Sherbrooke
2019-01-04
By invitation
Healthy People Initiative (HPI)
NCT03506867Nicotine Dependence, Substance Use Disorders
Ottawa Hospital Research Institute
Not applicable
250
Ottawa
2019-01-03
Recruiting
Pharmacogenetics of Antidepressant-Induced Disinhibition
NCT03953014Obsessive-Compulsive Disorder, Anxiety Disorders, Major Depressive Disorder, Antidepressant Drug Adverse Reaction
University of Calgary
Observational
120
Calgary
2019-01-02
Active, closed
A Study to Compare the Efficacy and Safety of Luspatercept (ACE-536) Versus Epoetin Alfa for the Treatment of Anemia Due to IPSS-R Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Participants Who Require Red Blood Cell Transfusions and Are ESA Naïve
NCT03682536Myelodysplastic Syndromes
DrugsEpoetin Alfa·Eprex·Luspatercept
Celgene
Phase 3
363
Calgary, Edmonton, Hamilton, Ottawa, Toronto, Montreal, Saskatoon, Sherbrooke
2019-01-02
Recruiting
MRI Assessment of Pulmonary Edema in Acute Heart Failure
NCT03999138Acute Heart Failure, Pulmonary Edema With Heart Failure
University of Alberta
Observational
300
Edmonton, Ottawa
2019-01-02
Recruiting
Multisite Inventory of Neonatal-Perinatal Interventions (MINI) Minimum Dataset
NCT05685745Infant, Extremely Premature, Obstetric Labor, Premature, Premature Birth, Intensive Care, Neonatal
The University of Texas Health Science Center, Houston
Observational
5,000
Surrey, Toronto
2019-01-01
Recruiting
Estab Biomarkers and Clinical Endpoints in Myotonic Dystrophy Type 1 (END-DM1)
NCT03981575Myotonic Dystrophy 1, DM1
Virginia Commonwealth University
Observational
700
Québec
2019-01-01
Active, closed
Adverse Long-term Consequences of Sleep Disordered Breathing: The Ottawa Hospital (TOH) Sleep Database
NCT03834792Polysomnography, Sleep Apnea Syndromes, Risk Factors, Prognosis
Ottawa Hospital Research Institute
Observational
5,155
Ottawa
2018-12-30
Active, closed
Long-term Safety, Tolerability and Effectiveness Study of Ofatumumab in Patients With Relapsing MS
NCT03650114Relapsing Multiple Sclerosis
Drugs13-valent pneumococcal conjugate vaccine·23-valent pneumococcal polysaccharide vaccine·Ofatumumab
Novartis Pharmaceuticals
Phase 3
1,882
London, Ottawa, Toronto, Gatineau, Greenfield Park, Montreal, Québec
2018-12-28
Active, closed
Trastuzumab Deruxtecan (DS-8201a) Versus Investigator's Choice for HER2-low Breast Cancer That Has Spread or Cannot be Surgically Removed [DESTINY-Breast04]
NCT03734029Breast Cancer
DrugsEribulin·Trastuzumab deruxtecan·Nab-paclitaxel·Capecitabine
Daiichi Sankyo
Phase 3
557
Calgary, Toronto, Montreal
2018-12-27
Active, closed
Study of Pembrolizumab (MK-3475) Versus Placebo in Combination With Neoadjuvant Chemotherapy & Adjuvant Endocrine Therapy in the Treatment of Early-Stage Estrogen Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative (ER+/HER2-) Breast Cancer (MK-3475-756/KEYNOTE-756)
NCT03725059Breast Cancer
DrugsEpirubicin·Doxorubicin·Cyclophosphamide·Paclitaxel
Merck Sharp & Dohme LLC
Phase 3
1,240
Edmonton, Vancouver, Toronto, Greenfield Park, Montreal, Québec, Trois-Rivières
2018-12-27
Active, closed
Efficacy and Safety of Pembrolizumab (MK-3475) in Combination With Bacillus Calmette-Guerin (BCG) in High-Risk Non-Muscle Invasive Bladder Cancer (HR NMIBC) (MK-3475-676/KEYNOTE-676)
NCT03711032High-risk Non-muscle Invasive Bladder Cancer
DrugsKeytruda·Pembrolizumab
Merck Sharp & Dohme LLC
Phase 3
1,397
Abbotsford British Columbia, Victoria, Moncton, Toronto, Chicoutimi, Montreal, Québec, Sherbrooke
2018-12-24
Active, closed
A Longitudinal Observational Study of Patients Undergoing Therapy for IMISC
NCT03661866Atopic Dermatitis, Alopecia Areata, Hidradenitis Suppurativa, Vitiligo
Target PharmaSolutions, Inc.
Observational
15,000
Peterborough, Richmond Hill, Montreal, Saskatoon
2018-12-21
Active, closed
A Study of Novel Anti-cancer Agents in Patients With Metastatic Triple Negative Breast Cancer
NCT03742102Triple Negative Breast Neoplasms
DrugsOleclumab·Capivasertib·Datopotamab Deruxtecan·Trastuzumab deruxtecan
AstraZeneca
Phase 1/2
243
Kelowna, London, Greenfield Park, Montreal
2018-12-21
Active, closed
Pharmacokinetics of IFX and TNF Concentrations in Serum, Stool, and Colonic Mucosa in Acute Severe Ulcerative Colitis
NCT03765450Ulcerative Colitis
DrugInfliximab
Alimentiv Inc.
Observational
18
Toronto
2018-12-21
Active, closed
Study of an Immunotherapeutic, DPX-Survivac, in Combination With Low Dose Cyclophosphamide & Pembrolizumab, in Subjects With Selected Advanced & Recurrent Solid Tumors
NCT03836352Ovarian Cancer, Hepatocellular Carcinoma, Non-small Cell Lung Cancer, Bladder Cancer
DrugsCyclophosphamide·Pembrolizumab
ImmunoVaccine Technologies, Inc. (IMV Inc.)
Phase 2
184
Brampton, Hamilton, Newmarket, Ottawa, Toronto, Montreal, Québec
2018-12-21
Recruiting
Study of Individuals Affected With Hypoplasminogenemia
NCT03797495Plasminogen Deficiency
Indiana Hemophilia &Thrombosis Center, Inc.
Observational
100
Windsor, Montreal, Québec, Saskatoon
2018-12-18
Active, closed
Choroidal Response to Novel Spectacle Lens to Control Myopia Progression
NCT03818880Myopia, Progressive
SightGlass Vision, Inc.
Not applicable
10
Waterloo
2018-12-18
Active, closed
A Study to Evaluate the Long-term Safety and Tolerability of Lucerastat in Adult Subjects With Fabry Disease
NCT03737214Fabry Disease
Idorsia Pharmaceuticals Ltd.
Phase 3
107
Calgary, London, Montreal, Vancouver, Winnipeg
2018-12-18
Active, closed
Study of Pembrolizumab Given Prior to Surgery and in Combination With Radiotherapy Given Post-surgery for Advanced Head and Neck Squamous Cell Carcinoma (MK-3475-689)
NCT03765918Head and Neck Neoplasms
DrugsKeytruda·Cisplatin·Pembrolizumab
Merck Sharp & Dohme LLC
Phase 3
714
Edmonton, Toronto, Montreal, Sherbrooke
2018-12-17
Recruiting
Anesthetics and Analgesics in Children
NCT03427736Anesthesia, Pain
DrugsHydromorphone·Oxycodone·Ketorolac·Morphine
Chi Dang Hornik
Observational
551
Toronto, Montreal
2018-12-13
Active, closed
Efficacy and Safety of Olaparib (MK-7339) in Participants With Previously Treated, Homologous Recombination Repair Mutation (HRRm) or Homologous Recombination Deficiency (HRD) Positive Advanced Cancer (MK-7339-002 / LYNK-002)
NCT03742895Advanced Solid Neoplasms
DrugOlaparib
Merck Sharp & Dohme LLC
Phase 2
329
Toronto, Montreal, Québec
2018-12-12
Active, closed
A Trial to Evaluate Efficacy and Safety of Ribociclib With Endocrine Therapy as Adjuvant Treatment in Patients With HR+/HER2- Early Breast Cancer
NCT03701334Early Breast Cancer
DrugRibociclib
Novartis Pharmaceuticals
Phase 3
5,101
Calgary, Edmonton, Kelowna, North Vancouver, Surrey, Vancouver, Halifax, Greater Sudbury
2018-12-07
Active, closed
A Study of Neoadjuvant/Adjuvant Durvalumab for the Treatment of Patients With Resectable Non-small Cell Lung Cancer
NCT03800134Non-Small Cell Lung Cancer
DrugsDurvalumab·Pemetrexed·Gemcitabine·Paclitaxel
AstraZeneca
Phase 3
825
Edmonton, Kitchener, Lévis, Montreal, Québec, Saskatoon
2018-12-06
Active, closed
TITRE III: Influenza B Immunogenicity Investigation
NCT03753347Influenza
British Columbia Centre for Disease Control
Phase 4
55
Vancouver
2018-12-01
By invitation
IVTCC 2.0: A Prospective Multicenter Ventricular Tachycardia Catheter Ablation Registry
NCT04520347Ventricular Arrhythmia, Ventricular Tachycardia, Premature Ventricular Contraction (PVC), Cardiomyopathy
University of California, Los Angeles
Observational
10,000
Montreal
2018-12-01
Recruiting
PSMA-PET: Deep Radiomic Biomarkers of Progression and Response Prediction in Prostate Cancer
NCT03594760Prostate Cancer
Centre hospitalier de l'Université de Montréal (CHUM)
Phase 3
1,000
Montreal
2018-12-01
Recruiting
Canadian SCAD Study
NCT04906356Spontaneous Coronary Artery Dissection, SCAD, Fibromuscular Dysplasia
Cardiology Research UBC
Observational
3,000
Vancouver
2018-12-01
Active, closed
Screening for Asymptomatic Coronary Artery Disease in Kidney Transplant Candidates
NCT03674307Cardiovascular Diseases, End Stage Renal Disease, Kidney Transplantation, Dialysis Related Complication
University of British Columbia
Not applicable
3,306
Edmonton, Vancouver, Halifax, Hamilton, Kingston, London, Ottawa, Toronto
2018-12-01
Active, closed
Feasibility Study of MET-4: Evaluating Fecal Microbiome Effects in Immunotherapy Patients
NCT03686202All Solid Tumors
University Health Network, Toronto
Phase 2/3
65
Toronto
2018-11-30
Active, closed
Edwards PASCAL CLASP IID/IIF Pivotal Clinical Trial
NCT03706833Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation
Edwards Lifesciences
Not applicable
1,247
Vancouver, Hamilton, Toronto, Montreal, Québec
2018-11-30
Active, closed
NOVOCART 3D Treatment Following Microfracture Failure
NCT03219307Articular Cartilage Defect
Aesculap Biologics, LLC
Phase 3
30
Edmonton, Halifax
2018-11-30
Active, closed
A Global Study to Evaluate Transarterial Chemoembolization (TACE) in Combination With Durvalumab and Bevacizumab Therapy in Patients With Locoregional Hepatocellular Carcinoma
NCT03778957Hepatocellular Carcinoma
DrugsDurvalumab·Bevacizumab
AstraZeneca
Phase 3
724
Ottawa, Toronto, Montreal
2018-11-30
Active, closed
A Study of Zolbetuximab (IMAB362) Plus CAPOX Compared With Placebo Plus CAPOX as First-line Treatment of Subjects With Claudin (CLDN) 18.2-positive, HER2-negative, Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma (GLOW).
NCT03653507Locally Advanced Unresectable Gastroesophageal Junction (GEJ) Adenocarcinoma or Cancer, Locally Advanced Unresectable Gastric Adenocarcinoma or Cancer, Metastatic Gastric Adenocarcinoma or Cancer, Metastatic Gastroesophageal Junction (GEJ) Adenocarcinoma
DrugsZolbetuximab·Capecitabine·Oxaliplatin
Astellas Pharma Global Development, Inc.
Phase 3
507
Chicoutimi, Rimouski, Calgary
2018-11-28
Active, closed
Savolitinib in Treating Patients With Recurrent or Refractory Primary CNS Tumors
NCT03598244Recurrent Diffuse Intrinsic Pontine Glioma, Recurrent Malignant Glioma, Recurrent Medulloblastoma, Recurrent Primary Central Nervous System Neoplasm
DrugSavolitinib
National Cancer Institute (NCI)
Phase 1
41
Toronto
2018-11-27
Active, closed
Multi-Center Study of GSK2857916 in Combination With Pomalidomide and Dex
NCT03715478Relapsed and/or Refractory Multiple Myeloma
DrugPomalidomide
Canadian Myeloma Research Group
Phase 1/2
120
Edmonton, Vancouver, Winnipeg, Halifax, Hamilton, London, Ottawa, Toronto
2018-11-26
Recruiting
Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases
NCT03550391Brain Metastases
DrugMemantine
Canadian Cancer Trials Group
Phase 3
206
Calgary, Edmonton, Vancouver, Halifax, Hamilton, London, Toronto, Greenfield Park
2018-11-22
Active, closed
Effects of Telemonitoring on the Outcome of Heart Failure Patients After an Incidence of Acute Decompensation
NCT03358303Heart Failure
University Health Network, Toronto
Not applicable
90
North York, Toronto
2018-11-16
Active, closed
Durvalumab+ Gemcitabine/Cisplatin (Neoadjuvant Treatment) and Durvalumab (Adjuvant Treatment) in Patients With MIBC
NCT03732677Muscle Invasive Bladder Cancer
DrugsDurvalumab·Gemcitabine·Cisplatin
AstraZeneca
Phase 3
1,063
Edmonton, Vancouver, London, Ottawa, Toronto, Montreal, Sherbrooke
2018-11-16
Active, closed
SBRT +/- Pembrolizumab in Patients With Local-Regionally Recurrent or Second Primary Head and Neck Carcinoma
NCT03546582Head and Neck Squamous Cell Carcinoma (HNSCC)
DrugsKeytruda·Pembrolizumab
RTOG Foundation, Inc.
Phase 2
86
Edmonton, Montreal
2018-11-14
Active, closed
MRI Screening Versus SYMptom-directed Surveillance for Brain Metastases Among Patients with Triple Negative or HER2+ MBC
NCT03881605Breast Neoplasm, Brain Metastases, Triple Negative Breast Cancer, HER2-positive Breast Cancer
Sunnybrook Health Sciences Centre
Not applicable
50
Toronto
2018-11-08
Recruiting
Single Fractions SBRT for Prostate Cancer
NCT04004312Prostate Cancer
Fabio Cury
Not applicable
12
Montreal
2018-11-07
Active, closed
Veliparib, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed Malignant Glioma Without H3 K27M or BRAFV600 Mutations
NCT03581292Anaplastic Astrocytoma, Glioblastoma, Malignant Glioma
DrugsVeliparib·Temozolomide
National Cancer Institute (NCI)
Phase 2
38
Calgary, Vancouver, St. John's, Halifax, Hamilton, Montreal, Québec
2018-11-06
Recruiting
International Severe Asthma Registry: Canadian Cohort
NCT04045587Severe Asthma
University of British Columbia
Observational
714
Edmonton, Vancouver, Kingston, London, Ottawa, Toronto, Montreal, Sherbrooke
2018-11-06
Active, closed
Multi-Omic Assessment of Squamous Cell Cancers Receiving Systemic Therapy
NCT03712566Cancer, Esophagus Squamous Cell Carcinoma, Squamous Cell Carcinoma of the Head and Neck, Anal Canal Squamous Cell Carcinoma
University Health Network, Toronto
Observational
39
Toronto
2018-11-06
Recruiting
Low-Dose Weekly vs High-Dose Cisplatin
NCT03649048Locally Advanced Head and Neck Squamous Cell Carcinoma
DrugCisplatin
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Not applicable
100
Hamilton, London, Toronto
2018-11-05
Active, closed
Paroxysmal Nocturnal Hemoglobinuria in ESUS & ETUS
NCT03329365Paroxysmal Nocturnal Hemoglobinuria, Embolic Stroke of Undetermined Source, Transient Ischemic Attack, Cerebral Vein Thrombosis
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Observational
200
London
2018-11-01
Recruiting
SABR for Renal Tumors
NCT03747133Renal Tumor
University Health Network, Toronto
Not applicable
90
Toronto
2018-11-01
Recruiting
Quebec Low Back Pain Study: Core Dataset
NCT04791891Low Back Pain
Laval University
Observational
10,000
Montreal
2018-11-01
Active, closed
Standardizing Care for Neuropsychiatric Symptoms and Quality of Life in Dementia
NCT03672201Alzheimer's Disease, Alzheimer Dementia (AD), Aggression
Centre for Addiction and Mental Health
Not applicable
187
Calgary, Kingston, London, Toronto, Whitby, Montreal
2018-11-01
Active, closed
CHORUS - Comprehensive HHT Outcomes Registry of the United States (Formerly OUR HHT Registry)
NCT04150822Hereditary Hemorrhagic Telangiectasia, HHT, Arteriovenous Malformation of Brain
Unity Health Toronto
Observational
296
Toronto
2018-11-01
Active, closed
Study on Olaparib Plus Abiraterone as First-line Therapy in Men With Metastatic Castration-resistant Prostate Cancer
NCT03732820Metastatic Castration-resistant Prostate Cancer
DrugsAbiraterone acetate·Olaparib
AstraZeneca
Phase 3
895
Calgary, Edmonton, Kelowna, Halifax, London, Toronto, Greenfield Park, Montreal
2018-10-31
Recruiting
Online Memory Intervention for Individuals with Traumatic Brain Injury
NCT04331392Brain Injuries, Traumatic, Brain Injury Traumatic Severe, Brain Injury Traumatic Moderate, Brain Injury, Chronic
Toronto Rehabilitation Institute
Not applicable
84
Toronto
2018-10-30
Recruiting
Non-Invasive Diagnosis of Pediatric Pulmonary Invasive Mold Infections
NCT03827694Pulmonary Invasive Fungal Infections, Pulmonary Invasive Aspergillosis
Arkansas Children's Hospital Research Institute
Observational
400
Toronto
2018-10-30
Recruiting
Deep TMS for Comorbid Depression and Cognitive Impairment in Older Adults
NCT03665831Major Depressive Disorder, Alzheimer Disease, Mild Cognitive Impairment
Rotman Research Institute at Baycrest
Not applicable
28
Toronto
2018-10-23
Active, closed
Comparing No Mechanical Bowel Preparation With Oral Antibiotics Alone in Patients Undergoing Elective Colon Surgery
NCT03663504Elective Colon Surgery
DrugMetronidazole
Ottawa Hospital Research Institute
Phase 4
630
Halifax, Ottawa, Renfrew, Toronto
2018-10-23
Active, closed
A Study Designed to Evaluate the Safety and Efficacy of Venetoclax Plus Dexamethasone (VenDex) Compared With Pomalidomide Plus Dexamethasone (PomDex) in Participants With t(11;14)-Positive Relapsed or Refractory Multiple Myeloma.
NCT03539744Multiple Myeloma
DrugsPomalidomide·Venetoclax·Dexamethasone
AbbVie
Phase 3
265
Calgary, Vancouver, Halifax, Lévis
2018-10-22
Active, closed
Conditioning SCID Infants Diagnosed Early
NCT03619551SCID
DrugBusulfan
Center for International Blood and Marrow Transplant Research
Phase 2
56
Montreal, Toronto, Winnipeg
2018-10-22
Active, closed
Regional Radiotherapy in Biomarker Low-Risk Node Positive and T3N0 Breast Cancer
NCT03488693Breast Cancer
Canadian Cancer Trials Group
Phase 3
2,138
Calgary, Edmonton, Abbotsford British Columbia, Kelowna, Prince George, Surrey, Vancouver, Victoria
2018-10-16
Active, closed
Physiotherapy Treatment for Gynecological Cancer Survivors With Urinary Incontinence
NCT03957434Gynecologic Cancer, Urinary Incontinence
Université de Sherbrooke
Not applicable
44
Sherbrooke
2018-10-16
Recruiting
Reducing Opioid Use for Chronic Pain Patients Following Surgery
NCT03675386Chronic Pain, Opioid Use, Postoperative Pain, Opioid Dependence
University Health Network, Toronto
Not applicable
210
Toronto
2018-10-15
Active, closed
Bevacizumab and Anetumab Ravtansine or Paclitaxel in Treating Patients With Refractory Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
NCT03587311Fallopian Tube Endometrioid Adenocarcinoma, Fallopian Tube High Grade Serous Adenocarcinoma, Ovarian Endometrioid Adenocarcinoma, Ovarian High Grade Serous Adenocarcinoma
DrugsAnetumab Ravtansine·Bevacizumab·Paclitaxel
National Cancer Institute (NCI)
Phase 2
96
Toronto
2018-10-12
Active, closed
A Comparison of Platinum-based Therapy With TSR-042 and Niraparib Versus Standard of Care (SOC) Platinum-based Therapy as First-line Treatment of Stage III or IV Nonmucinous Epithelial Ovarian Cancer
NCT03602859Ovarian Neoplasms, Ovarian, Fallopian Tube and Primary Peritoneal Carcinoma
DrugsNiraparib·Dostarlimab
Tesaro, Inc.
Phase 3
1,400
Vancouver, London, Toronto, Montreal, Sherbrooke, Windsor
2018-10-11
Recruiting
Measures of Respiratory Health Registry
NCT05501587Respiratory Disease, Cystic Fibrosis
University of British Columbia
Observational
1,000
Vancouver
2018-10-11
Active, closed
Vocal-cord vs. Complete Laryngeal Radiotherapy for Early Glottic Cancer
NCT03759431Cancer Neck, Larynx Cancer, Glottis Tumor
Centre hospitalier de l'Université de Montréal (CHUM)
Phase 2
155
London, Montreal
2018-10-11
Active, closed
Study of Telisotuzumab Vedotin (ABBV-399) in Participants With Previously Treated c-Met+ Non-Small Cell Lung Cancer
NCT03539536Non-small Cell Lung Cancer
DrugTelisotuzumab vedotin
AbbVie
Phase 2
270
Edmonton, Ottawa, Toronto, Greenfield Park
2018-10-10
Active, closed
A Study of Cabozantinib Compared With Placebo in Subjects With Radioiodine-refractory Differentiated Thyroid Cancer Who Have Progressed After Prior Vascular Endothelial Growth Factor Receptor (VEGFR) -Targeted Therapy
NCT03690388Differentiated Thyroid Cancer
DrugCabozantinib
Exelixis
Phase 3
187
Calgary, Edmonton, London, Toronto
2018-10-05
Recruiting
Spinal Anesthesia For Enhanced Recovery After Liver Surgery
NCT03715517Hepatectomy, Pain, Postoperative, Liver Neoplasms
DrugMorphine
University of Manitoba
Not applicable
128
Winnipeg
2018-10-04
Recruiting
Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants
NCT03511118Lactating Women on Select DOI, Breastfed Infants of Mothers on Select DOI
DrugsLabetalol·Nifedipine·Clindamycin·Oxycodone
Duke University
Observational
1,600
London, Montreal
2018-10-04
Active, closed
Pembrolizumab With or Without Anetumab Ravtansine in Treating Patients With Mesothelin-Positive Pleural Mesothelioma
NCT03126630Pleural Malignant Mesothelioma
DrugsAnetumab Ravtansine·Keytruda·Pembrolizumab
National Cancer Institute (NCI)
Phase 1/2
49
Toronto
2018-10-04
Active, closed
A Study of Ponatinib Versus Imatinib in Adults With Acute Lymphoblastic Leukemia
NCT03589326Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (Ph+ALL)
DrugsPonatinib·Imatinib·Vincristine·Methotrexate
Takeda
Phase 3
245
Vancouver, Ottawa, Greenfield Park, Montreal
2018-10-04
Active, closed
Palliative Thoracic ImmunoRT
NCT03705806Lung Cancer, Nonsmall Cell, Lung Cancer
University Health Network, Toronto
Observational
12
Toronto
2018-10-03
Active, closed
Integrative Sequencing In Germline and Hereditary Tumours
NCT03857594Hereditary Cancer Syndrome, High-Risk, Mutation, Germline Mutation
University Health Network, Toronto
Observational
10
Toronto
2018-10-02
Active, closed
CBF and NCF Changes With Brain Radiation
NCT03606421Neurocognitive Dysfunction, Brain Metastases
University Health Network, Toronto
Observational
110
Toronto
2018-10-01
Active, closed
Transcutaneous CO2 Monitoring at Home for Children With Neuromuscular Disease
NCT03478566Sleep Disorder; Breathing-Related, Central Apnea, Neuromuscular Diseases, Obstructive Sleep Apnea
The Hospital for Sick Children
Not applicable
39
Toronto
2018-10-01
Active, closed
Remplissage Versus Latarjet Coracoid Transfer for Recurrent Shoulder Instability
NCT03453710Shoulder Dislocation
Western University, Canada
Not applicable
30
Winnipeg, London
2018-10-01
Active, closed
Hypovolemic Phlebotomy to Reduce Blood Transfusions in Major Hepatic Resections
NCT03651154Liver Neoplasms, Hepatectomy, Blood Transfusion, Blood Loss, Surgical
Ottawa Hospital Research Institute
Not applicable
440
Vancouver, Ottawa, Montreal
2018-09-28
Active, closed
Study of Durvalumab + Tremelimumab, Durvalumab, and Placebo in Limited Stage Small-Cell Lung Cancer in Patients Who Have Not Progressed Following Concurrent Chemoradiation Therapy
NCT03703297Small Cell Lung Cancer
DrugsTremelimumab·Durvalumab
AstraZeneca
Phase 3
730
Edmonton, Toronto, Winnipeg, Hamilton, London, Ottawa, Montreal
2018-09-27
Active, closed
Study of Durvalumab Given With Chemotherapy, Durvalumab in Combination With Tremelimumab Given With Chemotherapy, or Chemotherapy in Patients With Unresectable Urothelial Cancer
NCT03682068Unresectable Locally Advanced Urothelial Cancer, Metastatic Urothelial Cancer
DrugsTremelimumab·Durvalumab·Gemcitabine·Cisplatin
AstraZeneca
Phase 3
1,246
Calgary, Edmonton, Vancouver, Hamilton, Ottawa, Toronto, Montreal
2018-09-27
Active, closed
Testing the Combination of Olaparib and Durvalumab, Cediranib and Durvalumab, Olaparib and Capivasertib, and Cediranib Alone in Recurrent or Refractory Endometrial Cancer Following the Earlier Phase of the Study That Tested Olaparib and Cediranib in Comparison to Cediranib Alone, and Olaparib Alone
NCT03660826Endometrial Adenocarcinoma, Endometrial Mixed Cell Adenocarcinoma, Endometrial Serous Adenocarcinoma, Endometrial Undifferentiated Carcinoma
DrugsCediranib Maleate·Capivasertib·Relatlimab·Olaparib
National Cancer Institute (NCI)
Phase 2
288
Toronto
2018-09-27
Active, closed
A Study to Evaluate the Safety and Efficacy of Mosunetuzumab (BTCT4465A) in Combination With Polatuzumab Vedotin in B-Cell Non-Hodgkin Lymphoma
NCT03671018B-cell Non-Hodgkin Lymphoma
DrugsMosunetuzumab·Polatuzumab Vedotin·Tocilizumab·Rituximab
Hoffmann-La Roche
Phase 1/2
422
Hamilton, Montreal, Saskatoon
2018-09-25
Active, closed
Assessment of Precision Irradiation in Early NSCLC and Interstitial Lung Disease
NCT03485378Non Small Cell Lung Cancer, Interstitial Lung Disease
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Not applicable
39
Edmonton, London, Toronto, Montreal
2018-09-20
Active, closed
Reducing Lung CongestIon Symptoms in Advanced Heart Failure
NCT03499236Heart Failure
V-Wave Ltd
Not applicable
605
Montreal, Québec
2018-09-19
Active, closed
Laser Vaginal Treatment for SUI
NCT03671694Stress Urinary Incontinence
Sunnybrook Health Sciences Centre
Not applicable
144
Toronto
2018-09-19
Active, closed
Safety and Efficacy of Pembrolizumab Compared to Placebo in Resected High-risk Stage II Melanoma (MK-3475-716/KEYNOTE-716)
NCT03553836Melanoma
DrugsKeytruda·Pembrolizumab
Merck Sharp & Dohme LLC
Phase 3
976
Edmonton, Winnipeg, Moncton, Ottawa, Toronto, Montreal, Québec
2018-09-12
Active, closed
Intestinal Inflammation in CF Patients
NCT04392544Cystic Fibrosis in Children, Cystic Fibrosis Gastrointestinal Disease, Cystic Fibrosis
The Hospital for Sick Children
Observational
100
Toronto
2018-09-11
Active, closed
Study of IMNN-001 (Also Known as GEN-1) With NACT for Treatment of Ovarian Cancer (OVATION 2)
NCT03393884Epithelial Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Cancer
DrugsIMNN-001·Paclitaxel·Carboplatin
Imunon
Phase 1/2
130
Montreal
2018-09-05
Recruiting
High Flow Nasal Cannula Versus Non-Invasive Ventilation in Exacerbations of Chronic Obstructive Pulmonary Disease
NCT03033251Exacerbation Copd, Acute Respiratory Distress, Acute Hypercapnic Respiratory Failure
Unity Health Toronto
Not applicable
30
Toronto
2018-09-02
Active, closed
The Minimally Invasive Coronary Surgery Compared to STernotomy Coronary Artery Bypass Grafting Trial
NCT03447938Coronary Artery Disease
Ottawa Heart Institute Research Corporation
Not applicable
176
Ottawa, Toronto
2018-09-01
Recruiting
ATrial Tachycardia PAcing Therapy in Congenital Heart
NCT03209583Atrial Arrhythmia, Atrial Tachycardia, Congenital Heart Disease, Pacemaker Re-Entrant Tachycardia
Ian Law
Observational
300
Toronto
2018-09-01
Recruiting
Calgary Registry for Advanced and Therapeutic Endoscopy
NCT04259580Biliary Disease, Pancreatic Diseases
University of Calgary
Observational
6,000
Calgary
2018-09-01
Active, closed
Short-Term Anticoagulation Versus Antiplatelet Therapy for Preventing Device Thrombosis Following Left Atrial Appendage Closure
NCT03568890Left Atrial Appendage Closure, Thrombosis, Stroke, TIA
DrugsEdoxaban·Clopidogrel
Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec
Phase 4
510
Québec
2018-09-01
Active, closed
Inference-Based Cognitive Therapy Versus Exposure and Response Prevention for Obsessive-Compulsive Disorder
NCT03677947Obsessive-compulsive Disorders and Symptoms, Obsessive-Compulsive Disorder
Centre de Recherche de l'Institut Universitaire en santé Mentale de Montréal
Not applicable
150
Montreal East
2018-09-01
Recruiting
Activating Cancer Communities Through an Exercise Strategy for Survivors
NCT03599843Cancer
Nova Scotia Health Authority
Not applicable
100
Halifax
2018-09-01
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Cite this view

Priya Life Science (2026). Clinical trial register: studies with a Canadian investigative site. Derived from ClinicalTrials.gov. Retrieved 28 September 2026. https://priyalifescience.com/clinical-trials-canada?page=58

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About this register

This register is built from ClinicalTrials.gov, the trial registry run by the U.S. National Library of Medicine. It includes every study on the registry that lists at least one investigative site in Canada and is recruiting, not yet recruiting, active but no longer recruiting, or enrolling by invitation: 6,540 studies in total at the last sync on 26 Sep 2026, 19:55 UTC. The full list can be downloaded as CSV or queried as JSON through the register API.

How many clinical trials are recruiting in Canada?

3,515 of the 6,540 studies in this register are recruiting new participants as of the 26 Sep 2026, 19:55 UTC sync. A further 629 have not yet opened recruitment, 2,212 are active but closed to new participants, and 184 are enrolling by invitation only. Eligibility for any study is decided by its study team.

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Browse trials by condition

Breast Cancer (136) Prostate Cancer (110) Cancer (75) Obesity (64) Multiple Myeloma (63) Stroke (57) Heart Failure (56) Ulcerative Colitis (43) Non-small Cell Lung Cancer (39) Type 2 Diabetes (39) Non-Small Cell Lung Cancer (38) Atrial Fibrillation (38) Healthy (36) Anxiety (35) Asthma (35)
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Browse trials by site location

Toronto (2809) Montreal (1902) Vancouver (1179) Calgary (1061) Edmonton (1017) Ottawa (872) London (871) Hamilton (809) Québec (678) Halifax (533) Winnipeg (455) Sherbrooke (265) Kingston (256) Kelowna (172) Brampton (147)
Listing here is informational and not medical advice; eligibility is determined by each study team. See also the Ireland, UK, EU, USA and China registers.