Acute Heart FailurePulmonary Edema With Heart Failure
Investigational drug(s) / intervention(s)
MRI
MRI: MRI studies (non-contrast) will consist of a free-breathing localizer (\~10 seconds) followed by a free-breathing yarnball water density scan, for a total MRI time of \< 3 minutes.
Study summary
Researchers are testing a more accurate way to measure how much fluid is in the lungs (also called pulmonary edema, or "increased lung water") in people with Heart Failure (HF) using MRI (Magnetic Resonance Imaging). There is little known about the exact level of lung water in patients with AHF or how these levels change from the time of hospital admission to discharge. The purpose of this research study is to measure the lung water in patients hospitalized for HF, to determine the change in lung water over the course of hospitalization and treatment, and to find out if lung water levels can predict if patients are higher or lower risk for returning to the hospital or dying from heart failure.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* 18 years of age or older and willing/able to provide informed consent
* patients being treated for acute heart failure (including those patients with both reduced and preserved ejection fraction)
* patients receiving medical therapy for pulmonary edema by current standard of care (including oral or IV diuretics)
* patients identified within 48 hours of initiation of medical therapy for pulmonary edema, defined as the time of first diuretic (IV or PO) or escalation of existing diuretic therapy administered within the ED or hospital
Exclusion Criteria:
* contraindication to MRI
* patient too critically ill/unstable as per the clinical care team for transport to MRI scanner within the required scanning window
* moderate to severe dementia
Primary outcome measure(s)
Magnitude of lung water density measured with MRI at Hospital Admission — Baseline (hospital admission) Lung water density (0-100%) is the fraction of lung tissue that contains water
Difference in lung water density measured with MRI at hospital admission and hospital discharge — 7 days Absolute change in lung water density from baseline (hospital admission) to hospital discharge. Lung water density will be 0%-100% at each time point.
Number and timing of clinical events and their statistical association with Outcome 1 (Magnitude of lung water density measured with MRI at Hospital Admission) — Up to 5 years Clinical events include cardiovascular hospitalization, cardiovascular emergency department visits or death
Number and timing of clinical events and their statistical association with Outcome 2 (Difference in lung water density measured with MRI at hospital admission and hospital discharge) — Up to 5 years Clinical events include cardiovascular hospitalization, cardiovascular emergency
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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