Alzheimer's Disease Treatment With Combination of 40Hz Light and Cognitive Therapy

Condition(s) studied

Investigational drug(s) / intervention(s)

Combination of 40Hz light and cognitive therapy (ALZLIFE): Combination of 40Hz light and cognitive therapy delivered by iPad application ALZLIFE

Study summary

Electrical activity in the brain known as "gamma" brainwaves help connect and process information throughout the brain. These gamma waves are diminished in Alzheimer's disease. New research in Alzheimer's disease mouse models shows that exposure to light flickering at the rate of 40 flashes per second or 40Hz increased gamma brainwaves and led to clearing of beta amyloid plaques in the brain, a key abnormality in Alzheimer's disease. This project will test the ability of a novel iPad App (AlzLife https://www.alz.life/) that delivers light therapy at 40 Hz combined with cognitive therapy to improve cognition, function, and quality of life in Alzheimer's disease.

Eligibility

Primary outcome measure(s)

• In-app cognitive test — through study completion, an average of 1 year
  The cognitive therapy delivered by ALZLIFE consist of cognitive games: Sudoku, Tic-Tac-Toe, Analog clock comparison, etc. The changes in performance score in these cognitive games are used to calculate the participant's Cognitive Index. Cognitive Index maximum score = 100. The lower score indicates worse performance.

Trial sites (1)

More Alzheimer's Light LLC trials in the USA

Other trials for the same condition