A Study to Learn How Well People With Bronchiectasis Tolerate Continued Treatment With Verducatib After Earlier Studies (AIRTIVITY®-ON)
Condition(s) studied
Study summary
This study is for adults and adolescents who are at least 12 years old and have bronchiectasis. People can participate if they completed a previous study with the study medicine called verducatib. The purpose of this study is to find out how well verducatib is tolerated when people with bronchiectasis take it for a long time. The study also looks at breathing problems, how often lung flare-ups happen, and how quickly lung function changes.
This is a roll-over study for participants who completed a previous study with verducatib: AIRTIVITY® (1397-0014) or CLAIRLEAF® (1397-0017). All participants receive verducatib. Participants take verducatib as tablets once a day at home. They may continue their usual treatment for bronchiectasis during the study.
Participants can stay in the study for up to 1 year and 9 months. Treatment with verducatib can continue for up to 1 year and 6 months. About 6 study visits are done at the study site and about 4 are done by phone. At all visits, the doctors check participants' health and collect information on any health problems that occur during the study. The doctors also look at lung flare-ups and measure lung function over time.
Eligibility
Primary outcome measure(s)
- Occurrence of treatment-emergent adverse events (TEAEs) over the course of this trial — up to 78 weeks
Trial sites (383)
| Facility | City | Region | Status |
|---|---|---|---|
| University of Arizona | Tucson | Arizona | |
| Newport Native MD, Inc | Newport Beach | California | |
| Paradigm Clinical Research - Redding | Redding | California | |
| University of California Davis | Sacramento | California | |
| National Jewish Health | Denver | Colorado | |
| Meris Clinical Research-Brandon-69466 | Brandon | Florida | |
| University of Florida College of Medicine | Jacksonville | Florida | |
| Mayo Clinic - Florida | Jacksonville | Florida | |
| Essence MD Research | Naples | Florida | |
| Vantage Clinical Trials - Tampa | Tampa | Florida | |
| Cleveland Clinic Florida | Weston | Florida | |
| Augusta University | Augusta | Georgia | |
| University of Kansas Medical Center | Kansas City | Kansas | |
| University of Michigan | Ann Arbor | Michigan | |
| Mayo Clinic, Rochester | Rochester | Minnesota | |
| HealthPartners Specialty Center 401 Building | Saint Paul | Minnesota | |
| Washington University School of Medicine | St Louis | Missouri | |
| University of Nebraska Medical Center | Omaha | Nebraska | |
| New York Medical College - Hawthorne | Hawthorne | New York | |
| Northwell Health | New Hyde Park | New York | |
| New York University Langone Medical Center | New York | New York | |
| Icahn School of Medicine at Mount Sinai | New York | New York | |
| New York Presbyterian Hospital -Columbia University | New York | New York | |
| Stern Research Partners, LLC | Huntersville | North Carolina | |
| Pinehurst Medical Clinic, Inc. - East | Pinehurst | North Carolina | |
| University of Cincinnati | Cincinnati | Ohio | |
| University Hospitals Cleveland Medical Center | Cleveland | Ohio | |
| Clinical Research Associates of Central PA | DuBois | Pennsylvania | |
| University of Pennsylvania | Philadelphia | Pennsylvania | |
| Jefferson Health Honickman Center | Philadelphia | Pennsylvania | |
| Medical University of South Carolina | Charleston | South Carolina | |
| Clinical Research of Rock Hill | Rock Hill | South Carolina | |
| Horizon Clinical Research Group | Cypress | Texas | |
| Baylor University Medical Center | Dallas | Texas | |
| University of Texas Southwestern Medical Center | Dallas | Texas | |
| El Paso Pulmonary Association | El Paso | Texas | |
| University of Texas Medical Branch at Galveston | Galveston | Texas | |
| Baylor College of Medicine | Houston | Texas | |
| Metroplex Pulmonary & Sleep Center | McKinney | Texas | |
| IMA Clinical Research San Antonio | San Antonio | Texas |
+ 343 more sites — see the full list on the official registry below.
More Boehringer Ingelheim trials in the UK
Other trials for the same condition
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT07915219 on ClinicalTrials.gov ↗ ← All trials in the UK