Whole-Body Vibration in Parkinson Disease

NCT07678983 · tracked via the Priya Life Science Turkey tracker

Sponsor

Izmir Bakircay University

Phase

Not applicable

Started

2026-01-20

Last updated

2026-07-14

Condition(s) studied

Parkinson's DiseaseBalanceGaitCognitive FunctionDual-Task PerformanceReaction Time

Investigational drug(s) / intervention(s)

Functional Exercise Based PhysiotherapyLow-Frequency Whole-Body Vibration TherapyMedium-Frequency Whole-Body Vibration Therapy

Functional Exercise Based Physiotherapy: A supervised functional exercise-based physiotherapy program will be conducted in a hospital setting twice per week for 8 weeks.

Low-Frequency Whole-Body Vibration Therapy: Whole-Body Vibration (WBV) will be applied as an adjunct to the functional exercise-based physiotherapy program. The intervention will be conducted in a hospital setting twice weekly for 8 weeks, with each session lasting 20 minutes. WBV will be applied to the low-frequency group at a frequency range of 3-10 Hz.

Medium-Frequency Whole-Body Vibration Therapy: Whole-Body Vibration (WBV) will be applied as an adjunct to the functional exercise-based physiotherapy program. The intervention will be conducted in a hospital setting twice weekly for 8 weeks, with each session lasting 20 minutes. WBV will be applied to the medium-frequency group at a frequency range of 12-20 Hz.

Study summary

The aim of this study is to evaluate the effects of different frequencies of Whole Body Vibration (WBV) application on balance, gait, cognitive functions, and dual-task performance in patients with Parkinson's disease.

Study Hypotheses:

H0.1 - There is no effect of different frequencies of WBV application on balance performance in patients with Parkinson's disease.

H1.1 - There is an effect of different frequencies of WBV application on balance performance in patients with Parkinson's disease.

H0.2 - There is no effect of different frequencies of WBV application on gait performance in patients with Parkinson's disease.

H1.2 - There is an effect of different frequencies of WBV application on gait performance in patients with Parkinson's disease.

H0.3 - There is no effect of different frequencies of WBV application on cognitive functions in patients with Parkinson's disease.

H1.3 - There is an effect of different frequencies of WBV application on cognitive functions in patients with Parkinson's disease.

H0.4 - There is no effect of different frequencies of WBV application on dual-task performance in patients with Parkinson's disease.

H1.4 - There is an effect of different frequencies of WBV application on dual-task performance in patients with Parkinson's disease.

H0.5 - There is no effect of different frequencies of WBV application on reaction time in patients with Parkinson's disease.

H1.5 - There is an effect of different frequencies of WBV application on reaction time in patients with Parkinson's disease.

H0.6 - There is no significant difference between medium-frequency and low-frequency WBV in terms of balance performance in patients with Parkinson's disease.

H1.6 - There is a significant difference between medium-frequency and low-frequency WBV in terms of balance performance in patients with Parkinson's disease.

H0.7 - There is no significant difference between medium-frequency and low-frequency WBV in terms of gait performance in patients with Parkinson's disease.

H1.7 - There is a significant difference between medium-frequency and low-frequency WBV in terms of gait performance in patients with Parkinson's disease.

H0.8 - There is no significant difference between medium-frequency and low-frequency WBV in terms of cognitive functions in patients with Parkinson's disease.

H1.8 - There is a significant difference between medium-frequency and low-frequency WBV in terms of cognitive functions in patients with Parkinson's disease.

H0.9 - There is no significant difference between medium-frequency and low-frequency WBV in terms of dual-task performance in patients with Parkinson's disease.

H1.9 - There is a significant difference between medium-frequency and low-frequency WBV in terms of dual-task performance in patients with Parkinson's disease.

H0.10 - There is no significant difference between medium-frequency and low-frequency WBV in terms of reaction time in patients with Parkinson's disease.

H1.10 - There is a significant difference between medium-frequency and low-frequency WBV in terms of reaction time in patients with Parkinson's disease.

Eligibility

Sex

ALL

Min age

30 Years

Max age

80 Years

Healthy volunteers

Inclusion Criteria * Individuals aged 30-80 years with a clinical diagnosis of Parkinson's disease. Hoehn and Yahr stages 1-3. * Stable medical treatment (no changes in medication for the past 4 weeks). * Willingness to participate and provision of written informed consent. * Score of 24 or higher on the Standardized Mini Mental State Examination (SMMSE). Exclusion Criteria * Advanced stage Parkinson's disease (Hoehn and Yahr stage \>3) or presence of severe motor complications. * History of surgical interventions or other neurological/vestibular disorders that may affect balance and gait (E.G., stroke, epilepsy, peripheral neuropathy). * Presence of severe cardiovascular or respiratory conditions that may affect stability (E.G., heart failure, uncontrolled hypertension, advanced COPD). * Conditions contraindicating whole-body vibration (WBV) application (E.G., severe osteoporosis, active thrombosis). * Psychiatric disorders or major depression that may interfere with treatment participation. * Significant communication or language impairments affecting participation. Withdrawal Criteria * Voluntary withdrawal from the study. * Development of health problems during the intervention that prevent completion of the study (E.G., unexpected acute illness or temporary medical condition). * Changes in medication or medical status during the study that may affect participation or performance. * Non-adherence to the protocol (attendance rate below 80% of sessions).

Primary outcome measure(s)

Mini Balance Evaluation Systems Test (Mini-BESTest) — Baseline and 8 weeks
Participants will be assessed while standing on a flat and firm surface. During the test, appropriate safety precautions will be taken if necessary to ensure participant safety. The assessment includes 4 subcomponents and 14 items: anticipatory postural adjustments, reactive postural control, sensory orientation, and dynamic gait. Each subcomponent represents different aspects of balance control and evaluates specific components of the postural control system. In each section of the assessment, participants will be asked to perform various functional tasks, and their performance will be observed during these tasks. The tasks include sit-to-stand and stand-to-sit transitions, standing balance, forward reach, backward stepping, standing with eyes closed, and turning while walking. Each item is scored on a 0-2 scale (0 = Severe İmpairment, 1 = Moderate İmpairment, 2 = Normal/No İmpairment), with a total score ranging from 0 to 28.
10 Meter Walk Test (10MWT) — Baseline and 8 weeks
Participants will be assessed while standing on a flat, firm, and non-slip surface. Participants will be asked to walk a 14 meter walkway, with the central 10 meter section used for timing. Walking speed will be recorded over this 10 meter distance. The test will be performed under two conditions: comfortable walking speed and maximum walking speed, with two trials for each condition. Completion time will be measured using a stopwatch, and walking speed will be calculated and expressed as meters per second (m/s) based on the average of the trials.

Trial sites (1)

Facility	City	Region	Status
Izmir Bakircay University Cigli Training and Research Hospital	Izmir	Turkey (Türkiye)

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07678983 on ClinicalTrials.gov ↗ ← All trials in Turkey