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Clinical Trials in Turkey / NCT07669688
Starting soon Observational

Pulse Wave Transit Time After Infraclavicular Block

NCT07669688 · tracked via the Priya Life Science Turkey tracker
Sponsor
Sakarya University
Phase
Observational
Started
2026-07-20
Last updated
2026-07-07

Condition(s) studied

Infraclavicular Brachial Plexus Block

Investigational drug(s) / intervention(s)

Ultrasound-guided infraclavicular brachial plexus block

Ultrasound-guided infraclavicular brachial plexus block: Ultrasound-guided infraclavicular brachial plexus block will be performed as part of routine clinical anesthesia practice for upper extremity surgery. Local anesthetic will be administered according to standard institutional protocols. No additional or experimental drug or procedure will be applied for research purposes. Pulse Wave Transit Time (PWTT) and other hemodynamic parameters will be recorded before and after block placement at predefined time intervals.

Study summary

This prospective observational study aims to evaluate the time-dependent changes in Pulse Wave Transit Time (PWTT) following ultrasound-guided infraclavicular brachial plexus block. PWTT is a non-invasive hemodynamic parameter reflecting vascular tone and sympathetic nervous system activity. Patients undergoing upper extremity surgery under infraclavicular block will be monitored using standard perioperative monitoring devices. PWTT measurements will be obtained before and after block placement at predefined time intervals. Secondary outcomes will include perfusion index, skin temperature, heart rate, blood pressure, respiratory rate, and oxygen saturation. The study seeks to determine whether PWTT can serve as an objective and non-invasive marker of sympathetic blockade following infraclavicular block.

Eligibility

Sex
ALL
Min age
18 Years
Max age
65 Years
Healthy volunteers
Accepted
Inclusion Criteria: * Patients undergoing elective upper extremity hand surgery * 18 - 65 years * ASA I * No coagulopathy, thrombocytopenia, coagulation disorders * Patients who provide informed consent to participate in the study Exclusion Criteria: * History of drug allergy relevant to study procedures or local anesthetics * Body mass index (BMI) ≥ 30 kg/m² * Body weight \< 40 kg * Age \< 18 years or \> 65 years * History of significant cardiac disease (e.g., arrhythmia, conduction abnormalities) * Coagulopathy (INR \> 1.5 or platelet count \< 100,000/mm³) * Pregnancy or lactation * Infection at the site of peripheral nerve block * ASA II-IV * Failed block or motor block duration exceeding 30 minutes * Patients reporting pain (NRS ≥ 3), due to potential influence on sympathetic activity * Chronic opioid use

Primary outcome measure(s)

  • Change in Pulse Wave Transit Time — 20 minutes after infraclavicular block
    The primary outcome is the time-dependent change in Pulse Wave Transit Time (PWTT) following ultrasound-guided infraclavicular brachial plexus block. PWTT will be measured as the interval between the R-wave of the electrocardiogram (ECG) and the corresponding pulse wave detected by peripheral pulse oximetry. Measurements will be recorded at baseline (pre-block) and at 0, 5, 10, 15, and 20 minutes after block placement. The primary analysis will evaluate the change in PWTT over time within the blocked extremity.

Trial sites (1)

FacilityCityRegionStatus
Sakarya University-Anesthesiology and Reanimation Department Sakarya Turkey (Türkiye)

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Other trials for the same condition

The Effect of Dexamethasone Adjuvant to Varying Doses of Bupivacaine on Motor and Sensory Blockade in Infraclavicular Brachial Plexus Blockade Active, not recruiting
Impact of Bupivacaine Dilution With Dextrose or Saline on Infraclavicular Block Outcomes Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07669688 on ClinicalTrials.gov ↗ ← All trials in Turkey