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Clinical Trials in Turkey / NCT07397884
Recruiting Observational

Markers of Bone Destruction and Oxidative Stress in Peri-implantitis

NCT07397884 · tracked via the Priya Life Science Turkey tracker
Sponsor
Saglik Bilimleri Universitesi
Phase
Observational
Started
2026-02-15
Last updated
2026-09-29

Condition(s) studied

Periodontal DiseasesPeriimplant Diseases

Study summary

The aim of this study is to evaluate and compare the levels of bone resorption (RANKL, OPG) and oxidative stress (Nitrotyrosine, NQO1) markers, along with pro-inflammatory cytokines (IL-1β), in the saliva and peri-implant sulcular fluid (PISF) of patients with peri-implantitis, periodontitis, and healthy individuals. The study seeks to determine the diagnostic value of these biomarkers in the early detection and progression of peri-implant diseases.

Eligibility

Sex
ALL
Min age
18 Years
Max age
65 Years
Healthy volunteers
Accepted
Inclusion Criteria: Systemically healthy volunteers aged 18-65. For Peri-implantitis group: Implants in function for ≥1 year, radiographic bone loss ≥ 2 mm, probing depth (PD) ≥ 5 mm, and presence of bleeding on probing (BOP) or suppuration. For Periodontitis group: At least one tooth with PD ≥ 4 mm, presence of BOP, and radiographic bone loss.For Healthy groups: PD ≤ 3 mm, no clinical inflammation (BOP-), and no radiographic bone loss. (According to the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases) - Exclusion Criteria:Presence of systemic diseases (e.g., diabetes, rheumatoid arthritis, osteoporosis). Use of antibiotics, anti-inflammatory, or immunosuppressive drugs within the last 3 months. Pregnancy or breastfeeding. Smoking (current smokers). History of periodontal or peri-implant surgical treatment within the last 6 months. Implant failure (mobility). Signs of acute infection (fever, systemic symptoms). \-

Primary outcome measure(s)

  • Salivary and Peri-implant Sulcular Fluid (PISF) IL-1β Levels. — At the baseline clinical examination (Day 0).
    The concentration of Interleukin-1 beta (IL-1β), a pro-inflammatory cytokine, will be measured in picograms per milliliter (pg/mL) using ELISA kits to evaluate the severity of inflammation and bone destruction.

Trial sites (1)

FacilityCityRegionStatus
Gülhane Faculty of Dentistry, University of Health Sciences Keçiören Ankara Recruiting

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Other trials for the same condition

Evaluation of the Effect of Smoking on Pyroptosis in Periodontal Pathogenesis Active, not recruiting
Retinal and Choroidal Changes in Periodontal Disease Starting soon
Evaluation of the Effectiveness of Odontogenic Grafts Obtained From Human Teeth on Bone Formation Enrolling by invitation
Evaluation of Salivary Gal-7, Gal-10 and MMP-9 Levels of Individuals With Different Periodontal Diseases Recruiting
Odontogenic Graft Obtained From Human Tooth and Low Level Laser Therapy Enrolling by invitation
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07397884 on ClinicalTrials.gov ↗ ← All trials in Turkey