Laser TherapyPeriodontal DiseasesBone Loss in JawAlveolar Bone LossPeriodontal Bone LossPeriodontal Atrophy
Investigational drug(s) / intervention(s)
Autogenous Tooth-Derived Bone GraftLow-Level Laser Therapy (LLLT)
Autogenous Tooth-Derived Bone Graft: Autogenous Tooth-Derived Bone Graft prepared using the BonMaker® ATB device from extracted human teeth. Following atraumatic tooth extraction, teeth will be mechanically ground and chemically processed according to the manufacturer's standardized protocol to obtain particulate autogenous graft material containing dentin and enamel components. The graft material will be placed immediately into extraction sockets for alveolar ridge preservation prior to implant placement.
Low-Level Laser Therapy (LLLT): Adjunctive low-level laser therapy (LLLT) performed using a 650 nm diode laser device (Woodpecker DTE D-Laser Blue) with a 6 mm fiber applicator in continuous contact mode at an output power of 25 mW and an energy density of 0.500 J/cm². Laser irradiation will be applied to grafted extraction sockets immediately after extraction, after flap closure, and during postoperative follow-up visits according to a standardized treatment protocol to enhance soft tissue healing and bone regeneration.
Study summary
This clinical trial aims to evaluate the effectiveness of an odontogenic graft obtained from extracted human teeth, with and without adjunctive low-level laser therapy (LLLT), on bone regeneration following posterior tooth extraction in systemically healthy adult patients. The study investigates whether the combination of autogenous tooth-derived graft material and LLLT enhances alveolar bone healing and preservation compared to grafting alone, prior to implant-supported posterior rehabilitation.
Eligibility
Sex
ALL
Min age
18 Years
Max age
65 Years
Healthy volunteers
Accepted
Inclusion Criteria:
* Patients requiring tooth extraction due to periodontal reasons (teeth with a hopeless prognosis), root caries, or root fractures, who are simultaneously candidates for posterior replacement with an osseointegrated implant, and who require extraction of at least two teeth.
* Integrity of the alveolar socket walls following tooth extraction.
* Patients who accept the study conditions, sign written informed consent, and agree to attend the scheduled follow-up visits.
Exclusion Criteria:
* General contraindications for dental and/or surgical treatments.
* Inflammatory or autoimmune diseases of the oral cavity.
* Uncontrolled diabetes mellitus (HbA1c \> 7%).
* History of malignancy requiring chemotherapy or radiotherapy within the past 5 years.
* Previous treatment with immunosuppressive agents, bisphosphonates, or high-dose corticosteroids.
* Smoking more than 10 cigarettes per day.
* Pregnant or breastfeeding women.
Primary outcome measure(s)
Mean change in horizontal alveolar ridge width (mm) from baseline to 4 months (CBCT) — Baseline (immediately after tooth extraction) and 4 months postoperatively (prior to implant placement) Horizontal alveolar ridge width will be measured in millimeters using cone-beam computed tomography (CBCT) at baseline (immediately after tooth extraction) and at 4 months postoperatively prior to implant placement.
The primary outcome will be defined as the mean change in ridge width (Δ width = width at 4 months - width at baseline), expressed in millimeters.
Trial sites (1)
Facility
City
Region
Status
Health Sciences University
Istanbul
Uskudar
More Istanbul Saglik Bilimleri University trials in Turkey
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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