Bacteria in Dental Plaque and Atheroma Plaque

Condition(s) studied

Investigational drug(s) / intervention(s)

atheroma plaque: During the endarterectomy procedure, samples will be collected for study from some of the atheroma plaques routinely taken for pathology from patients.

dental plaque: Subgingival plaque samples will be collected from patients before the endarterectomy procedure.

Study summary

Periodontitis is considered a focus of infection where oral bacteria, bacterial by-products or inflammatory mediators can interact with other parts of the organism via the blood. Periodontal pathogen components such as DNA, RNA or specific antigens of P. gingivalis, Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans), Treponema denticola (T. denticola), Fusobacterium nucleatum (F. nucleatum) or Campylobacter rectus have been isolated from different tissues such as atheroma plaques, placenta, amniotic sac and respiratory tract. It has been reported that periodontitis may contribute to endothelial dysfunction leading to the formation of atherosclerosis.

Eligibility

Primary outcome measure(s)

• Number of bacteria — through study completion, an average of 2 months
  Subgingival plaque
• Number of bacteria — through study completion, an average of 2 months
  atheroma plaque

Trial sites (1)

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