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Clinical Trials in Turkey / NCT07307339
Active, not recruiting Not applicable

The Acute Effects of Blood Flow Restriction on Ankle Muscle Reaction Time and Proprioception in Healthy Individuals

NCT07307339 · tracked via the Priya Life Science Turkey tracker
Sponsor
Uludag University
Phase
Not applicable
Started
2025-09-01
Last updated
2025-12-29

Condition(s) studied

Ankle ProprioceptionBlood Flow Restriction

Investigational drug(s) / intervention(s)

Blood Flow RestrictionSham Blood Flow Restriction

Blood Flow Restriction: Arm Description: Participants perform balance/proprioception tests under lower limb blood flow restriction at % 60 AOP.

Sham Blood Flow Restriction: Sham BFR Description: Participants perform the same tests with sham(20 mmHg) blood flow restriction

Study summary

his randomized controlled crossover study aims to investigate the acute effects of lower limb blood flow restriction (BFR) on ankle joint proprioception, postural control, and muscle activation in healthy adults. Each participant will complete test sessions under BFR (60% individualized arterial occlusion pressure) and control (20 mmHg sham) conditions. Outcome measures include joint position sense, kinesthesia, static and dynamic balance performance, and electromyographic (EMG) activity and reaction times of selected lower limb tibialis anterior and peroneus longus muscles.

Eligibility

Sex
ALL
Min age
18 Years
Max age
40 Years
Healthy volunteers
Accepted
Inclusion Criteria: * Aged between 18 and 40 years * No known neuromuscular or cardiovascular disease Exclusion Criteria: * History or presence of cardiac, coronary artery, or peripheral arterial disease * Presence or history of varicose veins, hypertension, diabetes mellitus, or pulmonary disease * History of pulmonary embolism or deep vein thrombosis * Use of medications affecting the central nervous or cardiovascular systems * Use of oral contraceptives or anticoagulants * Pregnancy * Open wounds or significant scar tissue at the cuff application site * History of lower extremity musculoskeletal injury or surgery * Any neurological, vascular, or systemic condition that may interfere with test performance

Primary outcome measure(s)

  • Change in Ankle Joint Position Sense Error (degrees) — day 1 and day 2
    Absolute error (degrees) between target and reproduced angles during passive and active joint position sense tests in inversion and plantar flexion, measured with an isokinetic dynamometer.
  • Static Balance Performance — day 3
    Center of pressure path length (mm) in single-leg and tandem stance with eyes open/closed on force platform (HUR SmartBalance).
  • Change in Kinesthesia Threshold (degrees) — day 1 and day 2
    Minimal angular displacement (degrees) at which movement is first perceived in inversion and plantarflexion.
  • Static balance performance — day 3
    sway velocity (mm/s) in single-leg and tandem stance with eyes open/closed on force platform (HUR SmartBalance).
  • static balance performance — day 3
    sway area (mm\^2) in single-leg and tandem stance with eyes open/closed on force platform (HUR SmartBalance).

Trial sites (1)

FacilityCityRegionStatus
Uludag University Bursa Turkey (Türkiye)

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07307339 on ClinicalTrials.gov ↗ ← All trials in Turkey