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Clinical Trials in Turkey / NCT06959017
Active, not recruiting Not applicable

Diffrence in Thromboprofilaksis in Elderly Ostoepenic Hip Fractures According to Mobility Status by Genetic Analysis

NCT06959017 · tracked via the Priya Life Science Turkey tracker
Sponsor
Saglik Bilimleri Universitesi
Phase
Not applicable
Started
2024-11-01
Last updated
2025-06-05

Condition(s) studied

Hip Fracture of Intertrochanteric TypeThromboembolic EventOsteopeniaThrombosis Embolism

Investigational drug(s) / intervention(s)

Gene Expression Analysis

Gene Expression Analysis: Each subject analysed for SERPİNH1 and ROCK1 gene exppression

Study summary

Hip fracture is a common and severe disease in elderly patients. The question of the study is whether elderly patients with severe osteopenia have significantly lower levels of the collagen-binding protein Hsp47 than relatively mobile patients due to advanced immobility before the fracture, and whether they participants have a similar risk of VTE to the normal population despite having had a hip fracture and surgery.

Eligibility

Sex
ALL
Min age
65 Years
Max age
—
Healthy volunteers
Accepted
Inclusion Criteria: * \>65 years of age * Interthrocanteric femur fracture AO Type 31A1, 31A2, 31A3 * Patients treated proksimal femoral nail * Minor trauma * Fracture mobility score 1,2,3,4,5 * Inial thrombocytes count 150.000-450.000 /µL Exclusion Criteria: * Body mass index \>40 * Fracture mobility score 6 (unknown type) * stage 4 chronic kidney disease * Patients with rheumatological diseases * Patients at serious risk of VTE(Venous thromboembolism) (according to the International Society on Thrombosis and Hemostasis, categorization of venous thromboembolism) : * Active Hematologic Cancer * Antiphospholipid syndrome * History of recurrent thrombosis (DVT) * Paroxysmal nocturnal hemoglobinuria

Primary outcome measure(s)

  • HSP 47 — Gene expression analysis will be performed once samples are collected from all participants.
    HSP 47 (SERPİNH1, ROCK1) gene expression analysis

Trial sites (1)

FacilityCityRegionStatus
Prof Dr emil Tascıoglu City Hospital Istanbul Şişli

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06959017 on ClinicalTrials.gov ↗ ← All trials in Turkey