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Clinical Trials in Turkey / NCT06874179
Starting soon Not applicable

Oropharyngeal Vs Intravenous Lidocaine Effects on Optic Nerve Sheath Diameter After Intubation

NCT06874179 · tracked via the Priya Life Science Turkey tracker
Sponsor
Ankara City Hospital Bilkent
Phase
Not applicable
Started
2025-03-20
Last updated
2025-03-13

Condition(s) studied

Endotracheal Intubation During SurgeryOptic Nerve Sheath Diameter

Investigational drug(s) / intervention(s)

Optic nerve sheath diameter measurement 0optic nerve sheath diameter measurement 1optic nerve sheath diameter measurement 2optic nerve sheath diameter measurement 3Pre-intubation oropharyngeal topical %10 lidocainePre-intubation intravenous %2 lidocaine

Optic nerve sheath diameter measurement 0: optic nerve sheath diameter (ONSD) measured via ultrasonography before intubation

optic nerve sheath diameter measurement 1: optic nerve sheath diameter measurement 1 via ultrasonography after intubation 1st minute

optic nerve sheath diameter measurement 2: optic nerve sheath diameter measurement via ultrasonography after intubation 5th minute

optic nerve sheath diameter measurement 3: optic nerve sheath diameter measurement via ultrasonography after intubation 10th minute

Pre-intubation oropharyngeal topical %10 lidocaine: Pre-intubation oropharyngeal topical %10 lidocaine

Pre-intubation intravenous %2 lidocaine: Pre-intubation intravenous %2 lidocaine

Study summary

This study aims to evaluate the effects of pre-intubation oropharyngeal topical lidocaine on optic nerve sheath diameter (ONSD) post-endotracheal intubation. The study will measure the ONSD using ultrasonography before intubation, and at 1, 5, and 10 minutes post-intubation. The results will be compared between patients receiving %10 lidocaine topically and %2 intravenous lidocaine.

Eligibility

Sex
ALL
Min age
18 Years
Max age
65 Years
Healthy volunteers
No
Inclusion Criteria: * ASA class I or II * Age 18-65 years * BMI 18-30 * No history or expected difficult intubation * No glaucoma or ocular pathology * No intracranial pressure increase Exclusion Criteria: * ASA class III and above * Obesity (BMI \> 30) * Difficult intubation history or risk * Glaucoma or other ophthalmic pathology * History of intracranial pressure increase or prior ophthalmic/intracranial surgery * Preoperative sedation * Active malignancy or ongoing radiotherapy/chemotherapy

Primary outcome measure(s)

  • Optic nerve sheath diameter 0 — Before intubation
    optic nerve sheath diameter (ONSD) measured via ultrasonography before intubation
  • Optic nerve sheath diameter 1 — 1 minute after intubation
    optic nerve sheath diameter (ONSD) measured via ultrasonography 1 minute after intubation
  • Optic nerve sheath diameter 2 — 5 minutes after intubation
    Optic nerve sheath diameter (ONSD) measured via ultrasonography 5 minutes after intubation
  • 0ptic nerve sheath diameter 3 — 10th minutes after intubation
    0ptic nerve sheath diameter (ONSD) measured via ultrasonography 10th minutes after intubation

Trial sites (1)

FacilityCityRegionStatus
Ankara Bilkent City Hospital Ankara Turkey

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06874179 on ClinicalTrials.gov ↗ ← All trials in Turkey