Mechanical Power Ventilation in RALP

Condition(s) studied

Investigational drug(s) / intervention(s)

Mechanical Power-Targeted Ventilation: Ventilation adjusted to achieve the lowest possible mechanical power (≤14 J/min) using titration of PEEP and respiratory rate.

Standard Ventilation: Conventional ventilation strategy with fixed PEEP (5 cmH₂O) and routine settings.

Study summary

Robot-assisted laparoscopic radical prostatectomy (RALP) requires steep Trendelenburg positioning and pneumoperitoneum, which adversely affect respiratory mechanics and may lead to impaired postoperative oxygenation.

Mechanical power (MP) has recently emerged as a comprehensive parameter reflecting the total energy delivered from the ventilator to the respiratory system and may be associated with ventilator-induced lung injury.

This prospective randomized controlled trial aims to evaluate whether a mechanical power-targeted ventilation strategy improves postoperative oxygenation compared to standard ventilation in patients undergoing RALP.

The primary outcome is the oxygenation index (OSI) at the postoperative second hour. Secondary outcomes include PaO₂/FiO₂ ratio, postoperative pulmonary complications, and length of hospital stay.

Eligibility

Primary outcome measure(s)

• Oxygenation Index (OSI) — postoperative 2nd hour
  OSI calculation: OSI = FiO₂ × MAP × 100 / SpO₂

Trial sites (1)

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