LDCT: LDCT at enrollment, annually for two years and biennially for 6 years if no lung cancer is detected
Study summary
This study utilizes the low dose computed tomography(LDCT) to detect the occurrence of early lung cancer among non-smokers in Taiwan. Subjects who have family history of lung cancer or have high risk exposures to lung cancer will be recruited to participate LDCT screening and followed up for their possible occurrence of lung cancer.
Eligibility
Sex
ALL
Min age
—
Max age
75 Years
Healthy volunteers
Accepted
Inclusion Criteria:
1. Never smokers or have smoked less than 10 pack-years and quitted smoking over 15 years.
2. age from 55 to 75 years for subjects without lung cancer family history; age 50-75 years for subjects with lung cancer family history (age less than 50 but older than the age at diagnosis of the youngest lung cancer proband is also eligible)
3. Having at least one of the following conditions:
(1)with family history of lung cancer within 1st, 2nd or 3rd degree relatives (2)with exposure history of environmental tobacco smoke in workplace or in home (3)history of chronic lung disease (Tuberculosis or COPD) (4)the cooking index equal or over than 110 \[cooking index = 2/7 x (days of cooking by pan frying, stir frying, or deep frying in one week) x (cooking years)\] (5)cooking without using cooking ventilation
Exclusion Criteria:
1. with history of lung cancer, or with cancers except skin cancer or cervical carcinoma in situ in the past 5 years
2. can not accept invasive diagnostic procedure or surgery
3. have been examined by chest computed tomography in the past 18 months
4. have unexplained hemoptysis in one month
5. weight loss over than 6 kg with unexplained reason among one year
6. pregnant
Primary outcome measure(s)
Validity of LDCT for lung cancer among non-smokers — 3 years True positive, false positive, true negative and false negative rates of LDCT on lung cancer screening. Each subject who is recognized as high risk to lung cancer will be recruited between 2014-2016.
Trial sites (17)
Facility
City
Region
Status
Chiayi Chang Gung Memorial Hospital
Chiayi City
Taiwan
Hualien Tzu Chi Hospital
Hualien City
Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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