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Recruiting Phase 2

Efficacy of L-menthol on Breathlessness in Asthma

NCT07500974 · tracked via the Priya Life Science Sweden tracker
Phase
Phase 2
Started
2026-05-07
Last updated
2026-08-19

Condition(s) studied

Asthma

Investigational drug(s) / intervention(s)

L-menthol →Placebo

L-menthol: (Sigma-Aldrich, St. Louis, US)

Placebo: Strawberry scent (Sigma-Aldrich, St. Louis, US)

Study summary

The purpose of this study is to assess the effect of L-menthol on breathlessness and exercise capacity in patients with Asthma.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * the subject has given written consent to participate in the study * physician diagnosis of Asthma according to international guidelines * mMRC (modified Medical Research Council) score of 1 or above * age 18 years or older * able to cycle * able to understand and talk Swedish to participate in the study procedures, as judged by the Investigators. Exclusion Criteria: * resting peripheral oxygen saturation (SpO2) \< 92% * hospitalization or clinical instability during the last four weeks * treatment with supplementary oxygen at rest or during exercise * contraindication to exercise testing in accordance with clinical practice guidelines * expected survival shorter than six months as judged by the Investigator * medical conditions including congestive heart failure, acute coronary artery disease, neuromuscular diseases, severe psychiatric illness, and olfaction disorder.

Primary outcome measure(s)

  • Breathlessness intensity — During submaximal test, at isotime during day 2 and day 3.
    The difference between treatment conditions in dyspnea intensity at iso-time. The Borg's modified 0-10 category ratio scale (Borg CR10) will be used, where 0 represents no perceived breathlessness at all, and 10 represents maximum breathlessness intensity ever experienced.

Trial sites (2)

FacilityCityRegionStatus
Blekinge Institute of Technology Karlskrona Blekinge County Not Yet Recruiting
Lund University hospital and Region Skåne Lund Sweden Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07500974 on ClinicalTrials.gov ↗ ← All trials in Sweden