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Clinical Trials in Sweden / NCT06069973
Recruiting Observational

Using Machine Learning and Biomarkers for Early Detection of Delayed Cerebral Ischemia

NCT06069973 · tracked via the Priya Life Science Sweden tracker
Sponsor
Sahlgrenska University Hospital
Phase
Observational
Started
2024-01-01
Last updated
2026-01-12

Condition(s) studied

Ischemic StrokeHemorrhagic Stroke

Investigational drug(s) / intervention(s)

No intervention, observational study

No intervention, observational study: No intervention

Study summary

The overall goal of this project is to determine if machine learning and analysis of neurospecific biomarkers can enable early detection of upcoming or ongoing cerebral ischaemia in patients suffering from subarachnoid haemorrhage with altered consciousness due to cerebral injury or sedation. Analyses of heart rate variability, electroencephalgraphy,nearinfrared spectroscopy, cerebral autoregulation, and brain injury specific biomarkers in blood and cerebrospinal fluid will be performed.

Eligibility

Sex
ALL
Min age
18 Years
Max age
110 Years
Healthy volunteers
No
Inclusion Criteria: Patients over the age of 18 with aneurysmal subarachnoid hemorrhage admitted to intensive care units at Sahlgrenska University hospital. Exclusion Criteria: * Unable to consent, * Cardiac arrythmia, * Previous brain damage

Primary outcome measure(s)

  • Early warning system — 2023-2033
    To develop a machine learning-based model that can identify patterns in signals obtained from HRV, NIRS, and EEG monitoring, which are consistent with upcoming cerebral ischemia and provide a warning about this to attending physicians. To define the specificity and time relation of neurospecific biomarkers in blood and cerebrospinal fluid in patients with subarachnoid haemorrhage with and without delayed cerebral ischemia to evaluate if any of these biomarkers can be used as an indicator for ongoing cerebral ischemia. To assess the prognostic value of changes in physiological and neurospecific biomarkers changes during the acute phase after subarachnoid hemorrhage on long-term outcome.
  • Autoregulation — 2023-2033
    xyz

Trial sites (1)

FacilityCityRegionStatus
Sahlgrenska University Hospital Gothenburg Sweden Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06069973 on ClinicalTrials.gov ↗ ← All trials in Sweden