A Study to Test How Different Doses of BI 1703880 in Combination With Ezabenlimab Are Tolerated in People With Different Types of Advanced Cancer (Solid Tumours)
Condition(s) studied
Investigational drug(s) / intervention(s)
BI 1703880: BI 1703880
Ezabenlimab: Ezabenlimab
Study summary
This study is open to adults with different types of advanced cancer. People can take part if previous treatment was not successful, or no treatment exists.
The purpose of this study is to find the highest dose of a medicine called BI 1703880 that people with advanced cancer can tolerate when taken together with ezabenlimab.
BI 1703880 and ezabenlimab are medicines that may help the immune system fight cancer. In this study, BI 1703880 is given to people for the first time.
Participants get BI 1703880 and ezabenlimab as infusions into a vein. During the first 6 weeks, they get BI 1703880 once a week. Later, they get BI 1703880 every 3 weeks. After the first 3 weeks, they get ezabenlimab in addition every 3 weeks.
Participants can get BI 1703880 for up to 1 year and ezabenlimab for up to 2 years as long as they benefit from treatment and can tolerate it. During this time, they visit the study site regularly. At these visits, the doctors check participants' health and take note of any unwanted effects.
Eligibility
Primary outcome measure(s)
- Occurrence of dose limiting toxicities (DLTs) during the maximum tolerated dose (MTD) evaluation period — up to 6 weeks
Trial sites (21)
| Facility | City | Region | Status |
|---|---|---|---|
| Valkyrie Clinical Trials | Los Angeles | California | Recruiting |
| Yale University School of Medicine | New Haven | Connecticut | Recruiting |
| John Theurer Cancer Center | Hackensack | New Jersey | Recruiting |
| Virginia Cancer Specialists, PC | Fairfax | Virginia | Not Yet Recruiting |
| National Cancer Center Hospital East | Chiba, Kashiwa | Japan | Recruiting |
| Saitama Medical University International Medical Center | Saitama, Hidaka | Japan | Recruiting |
| Japanese Foundation for Cancer Research | Tokyo, Koto-ku | Japan | Recruiting |
| Seoul National University Bundang Hospital | Seongnam | South Korea | Not Yet Recruiting |
| Severance Hospital | Seoul | South Korea | Not Yet Recruiting |
| Asan Medical Center | Seoul | South Korea | Not Yet Recruiting |
| Hospital Universitari Vall d'Hebron | Barcelona | Spain | Recruiting |
| Hospital Universitario Ramon Y Cajal | Madrid | Spain | Not Yet Recruiting |
| Hospital Universitario 12 de Octubre | Madrid | Spain | Not Yet Recruiting |
| CIO Clara Campal | Madrid | Spain | Recruiting |
| Instituto Valenciano de Oncología | Valencia | Spain | Recruiting |
| Hospital Clinico Universitario de Valencia | Valencia | Spain | Recruiting |
| National Cheng Kung University Hospital | Tainan | Taiwan | Not Yet Recruiting |
| National Taiwan University Hospital | Taipei | Taiwan | Not Yet Recruiting |
| The Royal Marsden Hospital, Chelsea | London | United Kingdom | Recruiting |
| Churchill Hospital | Oxford | United Kingdom | Recruiting |
| The Royal Marsden Hospital, Sutton | Sutton | United Kingdom | Recruiting |
More Boehringer Ingelheim trials in Spain
Other trials for the same condition
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT05471856 on ClinicalTrials.gov ↗ ← All trials in Spain