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Clinical Trials in South Korea / NCT07831044
Recruiting Not applicable

Analysis of Cerebrospinal Fluid Dynamics in Normal Pressure Hydrocephalus

NCT07831044 · tracked via the Priya Life Science South Korea tracker
Sponsor
Chungnam National University Hospital
Phase
Not applicable
Started
2025-09-11
Last updated
2026-09-21

Condition(s) studied

Normal Pressure Hydrocephalus

Investigational drug(s) / intervention(s)

Cerebrospinal fluid drainge

Cerebrospinal fluid drainge: Cerebrospinal fluid drainge

Study summary

This study aims to evaluate whether phase-contrast magnetic resonance imaging (MRI)-based cerebrospinal fluid (CSF) flow dynamics can improve the diagnosis and prognostic assessment of normal pressure hydrocephalus (NPH). In addition, the study investigates how changes in CSF flow parameters before and after CSF diversion procedures are associated with clinical improvement.

Eligibility

Sex
ALL
Min age
55 Years
Max age
80 Years
Healthy volunteers
No
Inclusion Criteria: * Patients presenting with clinical symptoms consistent with normal pressure hydrocephalus (presence of gait disturbance accompanied by at least one of the following: cognitive impairment or urinary dysfunction) * Evans' ratio ≥ 0.3 on brain MRI Exclusion Criteria: * Patients who cannot undergo CSF drainage due to structural abnormalities of the lumbar spine * Contraindications to lumbar puncture and CSF drainage (e.g., local infection at the puncture site, suspected elevated intracranial pressure, platelet count \< 40,000/µL, or coagulopathy) * Coexisting neurological disorders that can also cause gait disturbance, such as Parkinson's disease, atypical parkinsonian syndromes, or vascular parkinsonism * Contraindications to MRI (e.g., presence of cardiac pacemakers, implantable defibrillators, or other non-MRI-compatible implantable medical devices)

Primary outcome measure(s)

  • Change from Baseline in Cerebrospinal Fluid Flow Velocity (cm/s) at 30 Minutes Post-Procedure — Baseline (Pre-intervention) and 30 minutes post-intervention
    Assessment of cerebrospinal fluid flow parameters before and after the procedure.

Trial sites (1)

FacilityCityRegionStatus
Chungnam National University Hospital Daejeon Jung-gu Recruiting

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Other trials for the same condition

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07831044 on ClinicalTrials.gov ↗ ← All trials in South Korea