nothing: Follow-up observation was conducted without any intervention in an outpatient setting.
Study summary
The objective of this observational study is to provide basic data for predicting and analyzing the occurrence and causes of delayed cognitive impairment, an important factor in the quality of life, among discharged patients who have received targeted temperature management therapy and experienced favorable neurological outcomes after out-of-hospital cardiac arrest.
The main questions it aims to answer are:
* Can we identify abnormal areas in the brains of patients with delayed cognitive impairment using Brain MRI or positron emission tomography (PET) imaging?
* Is it possible to predict delayed cognitive impairment using biomarkers?
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Patients who visited the hospital emergency room due to cardiac arrest within 60 months after Institutional Review Board (IRB) approval
* Patients with Glasgow Coma Scale (GCS) less than 8 points after spontaneous circulation recovery
* Patients who are 18 years old or older
* Patients who underwent targeted temperature management (TTM)
* Patients who showed good neurological outcomes with CPC 1-2 points after evaluating the prognosis on days 10-14 after ROSC
Exclusion Criteria:
* Under 18 years of age
* cardiac arrest cause is trauma
* Patients who have not undergone targeted temperature management
* Patients treated with extracorporeal membrane oxygenation (ECMO)
* Patients who were not able to undergo SNSB testing
* Patients who could not be followed up until 6 months after ROSC
Primary outcome measure(s)
Change in cognitive impairment — at 10-14 days, 3 months, and 6 months after return of spontaneous circulation Through the Seoul Neuropsychological Screening Battery (SNSB), attention, language and related functions, visuospatial function, memory, frontal lobe and executive function, and other related functions can be assessed. The test is conducted by a specialist clinical psychologist for 1 hour and 30 minutes to 2 hours, and the results are analyzed by Professor Oh Eung-Seok, a neurologist.
Trial sites (1)
Facility
City
Region
Status
박정수
Daejeon
Seo-gu
More Chungnam National University Hospital trials in South Korea
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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