Molecular Insights Into Post-Cardiac Arrest Brain Injury Via CSF Multi-Omics

Condition(s) studied

Study summary

The goal of this study is to uncover the molecular mechanisms responsible for secondary brain injury in patients with post-cardiac arrest syndrome by analyzing cerebrospinal fluid (CSF) using multi-omics techniques.

The main question this study aims to answer is:

Which genome-, transcriptome-, proteome-, and metabolome-level changes in CSF are associated with secondary brain injury after cardiac arrest?

To address this question, CSF samples collected from post-cardiac arrest patients will undergo multi-omics analyses. Identified molecular pathways will be used to screen existing drug databases and generate new therapeutic candidates through computational modeling and compound synthesis. These findings will provide the scientific foundation needed to design and implement future preclinical experiments using cardiac arrest animal models.

Eligibility

Primary outcome measure(s)

• Neurological outcome — at discharge (assessed up to 3 days), 3 months after return of spontaneous circulation (ROSC)
  Neurological outcome assessed using the Cerebral Performance Category (CPC) scale (range 1-5; lower scores indicate better neurological function).

Trial sites (1)

More Chungnam National University Hospital trials in South Korea

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