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Clinical Trials in South Korea / NCT06479122
Recruiting Phase 4

Efficacy of Acetaminophen Alone Versus Combination of Acetaminophen/Ibuprofen After Cesarean Section

NCT06479122 · tracked via the Priya Life Science South Korea tracker
Sponsor
Seoul National University Hospital
Phase
Phase 4
Started
2024-10-09
Last updated
2025-06-04

Condition(s) studied

Cesarean SectionPostoperative Pain

Investigational drug(s) / intervention(s)

Acetaminophen →Acetaminophen/IbuprofenAcetaminophen →Acetaminophen/Ibuprofen

Acetaminophen: 1g acetaminophen is administered during skin closure (end of operation).

Acetaminophen/Ibuprofen: A mixture of 1g acetaminophen and 300 mg ibuprofen (Maxigesic®IV) is administered during skin closure (end of operation)

Acetaminophen: 1g acetaminophen is administered 6 hours after the first administration.

Acetaminophen/Ibuprofen: A mixture of 1g acetaminophen and 300 mg ibuprofen (Maxigesic®IV) is administered 6 hours after the first administration.

Study summary

The investigators aim to compare the analgesic efficacy of intravenous acetaminophen alone versus combination of acetaminophen/ibuprofen (Maxigesic®IV) in multimodal analgesia after cesarean section.

Eligibility

Sex
FEMALE
Min age
19 Years
Max age
—
Healthy volunteers
Accepted
Inclusion Criteria: * Patients scheduled for elective cesarean section * Gestational age \> 37+0 weeks Exclusion Criteria: * Emergency cesarean section * Multiple pregnancy (e.g. twins, triplets) * Body weight \< 50 kg * Preeclampsia * History of hypersensitivity to acetaminophen or ibuprofen * History of upper gastrointestinal tract bleeding or gastric ulcer * Underlying liver disease * Underlying kidney disease or GFR \< 90 mL/min/1.73m2 * Heart failure or severe hypertension * History of asthma * Chronic use of barbital or tricyclic antidepressants

Primary outcome measure(s)

  • Obstetric QoR-11K score 24 hours after end of surgery — 24 hours after end of surgery
    Minimum 0, poor recovery; maximum 110, good recovery

Trial sites (1)

FacilityCityRegionStatus
Seoul National University Hospital Seoul South Korea Recruiting

On this site

📄 Tylenol (acetaminophen) drug profile →

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Other trials for the same condition

Timing of Subcostal TAPB Combined With Rectus Sheath Block for Postoperative Pain After Laparoscopic Cholecystectomy Recruiting
Comparison of the Postoperative Analgesic Effects of the Temperature-responsive Gel Mixed With Local Anesthetics Application and Ultrasound-guided Transversus Abdominis Plane Block in Patients Undergoing Laparoscopic Gastrectomy Starting soon
Analgesia Nociception Index in Orthognathic Surgery Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06479122 on ClinicalTrials.gov ↗ ← All trials in South Korea