SII Levels Following PENG Block in Pediatric Hip Surgery

NCT07607535 · tracked via the Priya Life Science Poland tracker

Sponsor

Poznan University of Medical Sciences

Phase

Not applicable

Started

2026-06-01

Last updated

2026-05-26

Condition(s) studied

Hip Dysplasia

Investigational drug(s) / intervention(s)

Ropivacaine 0.2% Injectable Solution →0.9%NaCl →

Ropivacaine 0.2% Injectable Solution: Ultrasound-guided regional anesthesia technique targeting the articular branches of the hip joint to provide postoperative analgesia.

0.9%NaCl: Simulated procedure performed to maintain blinding without administration of local anesthetic.

Study summary

This study is a prospective, randomized, double-blind clinical trial. Its aim is to evaluate whether adding a pericapsular nerve group (PENG) block to spinal anesthesia can reduce the inflammatory response after hip surgery in children.

Hip surgery in children can cause a strong stress and inflammatory reaction, which may affect pain after surgery, the need for opioid medications, and recovery.

Children aged 3 to 8 years will be randomly assigned to one of two groups: spinal anesthesia alone or spinal anesthesia combined with a PENG block. The main goal is to compare changes in the Systemic Immune-Inflammation Index (SII), a blood-based marker of inflammation, measured before surgery and 24 hours after surgery.

Additional outcomes include other inflammatory markers, postoperative pain, opioid use, time to first rescue pain medication, and side effects.

Eligibility

Sex

ALL

Min age

3 Years

Max age

8 Years

Healthy volunteers

Inclusion Criteria: * Age 3-8 years * Scheduled for elective unilateral hip surgery * American Society of Anesthesiologists (ASA) physical status I-III * Written informed consent from the parent or legal guardian Exclusion Criteria: * Contraindications to spinal anesthesia or PENG block * Infection at the planned needle insertion site * Coagulation disorders * Chronic immunosuppressive therapy or chronic steroid use * Active infection or inflammatory disease * Ongoing oncological treatment * Known allergy to local anesthetics or study-related medications * Conversion to general anesthesia * Refusal to participate

Primary outcome measure(s)

Systemic Inflammation Response Index (SIRI) — 12 hours after surgery
Systemic Inflammation Response Index (SIRI) is used as a composite marker of systemic inflammatory activation. It is calculated from peripheral venous blood samples using the formula: SIRI = (Neutrophil count × Monocyte count) / Lymphocyte count All parameters are obtained from routine complete blood count (CBC) analysis and expressed in ×10⁹/L. SIRI reflects the interaction between innate immune activation (neutrophils and monocytes) and adaptive immune suppression (lymphocytes). Higher SIRI values indicate greater systemic inflammatory response.

Trial sites (1)

Facility	City	Region	Status
Poznan University of Medical Sciences	Poznan	Poland

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Other trials for the same condition

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07607535 on ClinicalTrials.gov ↗ ← All trials in Poland